Hydroxyurea Associated Cutaneous Lesions: A Case Report

Open Access Macedonian Journal of Medical Sciences
Viktor SimeonovskiSuzana Nikolovska

Abstract

Hydroxyurea (HU) is an antimetabolite agent that interferes with the S-phase of cellular replication and inhibits DNA synthesis, with little or no effect on RNA or protein synthesis. It is used in the treatment of many myeloproliferative disorders (MD) and is particularly a first line treatment drug for intermediate to high-risk essential thrombocythemia. Although safe and very well tolerated by the patients suffering from MD, there have been numerous reports of a broad palette of cutaneous side effects associated with prolonged intake of the medication. These may include classical symptoms such as xerosis, diffuse hyperpigmentation, brown-nail discolouration, stomatitis and scaling of the face, hands, and feet or more serious side effects such as actinic keratosis lesions, leg ulcers and multiple skin carcinomas. We report a case of a 52-year-old man, on long-term therapy with HU for essential thrombocytosis, with several concurrent skin lesions. Despite the perennial use of HU, the cutaneous changes were neglected. The local dermatological examination revealed oval perimalleolar ulcer on the right leg, with dimensions 6 x 4 cm, clearly demarcated from the surroundings with regular margins, periulcerous erythema, with very dee...Continue Reading

Citations

Sep 6, 2019·Dermatologic Therapy·Duygu GülserenYahya Büyükaşık
Jun 4, 2020·International Journal of Molecular Sciences·Alessandra MalatoNovella Pugliese
Dec 14, 2019·World Journal of Clinical Cases·Yan Xu, Jian Liu
Nov 13, 2020·International Journal of Dermatology·Camille A BulteAmor Khachemoune
Mar 3, 2021·Orphanet Journal of Rare Diseases·Nirmani YasaraSachith Mettananda
Jul 13, 2021·International Journal of Surgery Case Reports·Ouassime KerdoudFaiçal Slimani

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biopsy

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