PMID: 5858026Dec 24, 1965

Hydroxyurea: differential lethal effects on cultured mammalian cells during the cell cycle

W K Sinclair


Hydroxyurea has a differential lethal effect on cultured Chinesehamster cells that are at different stages in their cell cycle. Cells synthesizing DNA at the time of exposure to the drug are lethally damaged. Cells in the phase of growth preceding DNA synthesis (G(1)) survive but are prevented from beginning DNA synthesis. Cells in the phase after DNA synthesis (G(2)) survive and appear to progress until just before the beginning of the next period of DNA synthesis. This differential lethal and inhibitory effect of hydroxyurea may be useful for synchronizing asynchronous cell populations and explaining effects of the drug in human therapy.


Sep 1, 1978·Head & Neck Surgery·M R Green
Nov 1, 1968·The Journal of Clinical Pharmacology and the Journal of New Drugs·H B Nevinny, T C Hall
Jan 1, 1980·Journal of Cancer Research and Clinical Oncology·H O KleinG Akokan
Oct 1, 1978·Biulleten' eksperimental'noĭ biologii i meditsiny·L V Van'koB B Fuks
Jan 1, 1981·Archives of Virology·I Takashima, C Olson
Jan 1, 1971·In Vitro·G F Whitmore
Dec 21, 2000·Current Oncology Reports·J M Schilder, F B Stehman
May 1, 1974·Life Sciences·H S InjeyanJ McLaughlin
Dec 1, 1976·Mutation Research·M Adams, J R Warr
Nov 28, 1986·Mechanisms of Ageing and Development·M MoriN Sato
Jan 1, 1979·Pharmacology & Therapeutics·F A Valeriote
Jan 1, 1976·Mutation Research·P M Aebersold, H J Burki
Jan 26, 1982·Biochimica Et Biophysica Acta·T L BoehmD Drahovsky
Jan 1, 1982·International Journal of Radiation Oncology, Biology, Physics·M M Elkind
Feb 1, 1995·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D K HansenS J James
Jan 1, 1990·Reproductive Toxicology·J M DeSesso, G C Goeringer
Sep 1, 1969·Biophysical Journal·A Han, W K Sinclair
Jul 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·W K Sinclair
Jul 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·F Mauro, H Madoc-Jones
Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R M Yanishevsky, D M Prescott
Jul 1, 1966·The Journal of Cell Biology·R D Estensen, R Baserga
Aug 1, 1969·The Journal of Cell Biology·M M ElkindH Sutton-Gilbert
Sep 1, 1971·The Journal of Cell Biology·S G Sawicki, G C Godman
Mar 1, 1972·The Journal of Cell Biology·F E Stockdale, M C O'Neill
May 1, 1974·The Journal of Experimental Medicine·H P LohrmannR G Graw
Feb 1, 1975·The Journal of Experimental Medicine·P Häyry, L C Andersson

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