Hydroxyurea therapy lowers TCD velocities in children with sickle cell disease

Pediatric Blood & Cancer
Tonya KratovilCaterina P Minniti

Abstract

Hydroxyurea (HU) improves hematologic parameters and decreases adverse events in patients with sickle cell disease (SCD). HU has been proposed as an alternative to chronic transfusions for secondary stroke prevention. Transcranial doppler (TCD) is an accepted method of stroke risk stratification in patients with SCD. We sought to determine if HU affects TCD velocities in children with SCD. A cohort of 24 children with HbSS with a baseline TCDi prior to HU and a follow-up after at least 6 months of therapy was analyzed. Twenty-four age-matched children with HbSS formed the control group. Differences in hematologic parameters before and after HU therapy were evaluated. TCDi velocities decreased in the HU-treated patients. The adjusted mean change in TCDi velocities was -13.0 cm/sec (95% CI -20.19, -5.92) in the HU-treated group and +4.72 cm/sec (95% CI -3.24, 12.69) in the controls. Changes in TCDi between the two groups were statistically significant (P < 0.001). Changes in hematologic parameters were not predictive of changes in TCDi velocities in the treated patients. Four out of five patients with TCDi velocities >170 cm/sec had normalization of TCDi velocities on HU. Mean change was -34.75 cm/sec in this subgroup. No patient...Continue Reading

References

Nov 1, 1976·American Journal of Epidemiology·C E Davis
Mar 1, 1992·The Journal of Pediatrics·B BalkaranG R Serjeant
Feb 27, 1992·The New England Journal of Medicine·R AdamsD Hess
Nov 1, 1994·Stroke; a Journal of Cerebral Circulation·N VenketasubramanianS Piomelli
Jun 1, 1996·The Journal of Pediatrics·J P ScottR J Labotka
Oct 1, 1996·The Journal of Pediatrics·S JayaboseP Visintainer
Aug 26, 2000·Journal of Pediatric Hematology/oncology·C HoppeL Styles
Dec 18, 2001·The Journal of Pediatrics·W C WangR E Ware
Apr 4, 2003·JAMA : the Journal of the American Medical Association·Martin H SteinbergMichael Terrin

❮ Previous
Next ❯

Citations

Apr 7, 2007·Current Opinion in Hematology·Winfred C Wang
Dec 20, 2012·Journal of Pediatric Hematology/oncology·Arunodaya R GujjarAnil Pathare
Jan 1, 2011·Revista brasileira de hematologia e hemoterapia·Clarisse Lopes de Castro LoboViviane Flumignan Zetola
Nov 21, 2013·Pediatric Research·Nancy S Green, Sandra Barral
Jun 21, 2013·Expert Review of Hematology·Jennifer Webb, Janet L Kwiatkowski
Nov 14, 2008·Expert Opinion on Pharmacotherapy·Winfred C Wang
Jan 14, 2016·Blood·Michael R DeBaun, Fenella J Kirkham
Oct 9, 2014·Blood Cells, Molecules & Diseases·Ross M FasanoMonica L Hulbert
Jun 16, 2012·Ultrasound in Medicine & Biology·Florian DoeppStephan J Schreiber
Feb 2, 2010·Hematology/oncology Clinics of North America·Matthew M Heeney, Russell E Ware
Apr 3, 2008·Pediatric Clinics of North America·Matthew M Heeney, Russell E Ware
Oct 24, 2006·Current Problems in Pediatric and Adolescent Health Care·Rupa Redding-Lallinger, Christine Knoll
Dec 9, 2008·Pediatric Blood & Cancer·Courtney D ThornburgRussell E Ware
Nov 28, 2008·British Journal of Haematology·Sara Trompeter, Irene Roberts
May 15, 2008·British Journal of Haematology·Jane S HankinsRussell E Ware
Nov 16, 2012·Pediatric Blood & Cancer·Timothy L McCavitCharles T Quinn
Jan 7, 2010·American Journal of Hematology·Rachael F GraceAlejandro Gutierrez
Oct 25, 2006·Mental Retardation and Developmental Disabilities Research Reviews·F Daniel Armstrong
Oct 6, 2016·Pediatric Research·Emily Riehm Meier, Angeli Rampersad
Feb 22, 2017·Journal of Pediatric Hematology/oncology·Nathan MenakerLauren Weintraub
May 8, 2018·British Journal of Haematology·Amrana QureshiUNKNOWN British Society for Haematology
Oct 31, 2014·Stroke; a Journal of Cerebral Circulation·James F MeschiaUNKNOWN Council on Hypertension
Dec 4, 2010·Stroke; a Journal of Cerebral Circulation·Larry B GoldsteinUNKNOWN Council on Peripheral Vascular Disease, and Interdisciplinary Council on Quality of Care and Outcomes Research
Nov 15, 2018·Clinical Trials : Journal of the Society for Clinical Trials·James F CasellaHarold P Lehmann
Apr 9, 2014·The Cochrane Database of Systematic Reviews·Robert Dunlop, Kyle C L B Bennett
Aug 5, 2017·British Journal of Haematology·John BrewinSubarna Chakravorty
Aug 9, 2017·Journal of Pediatric Hematology/oncology·Susan ZamaniMohammad R Bordbar
Feb 6, 2018·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Sawsan M MoeenMedhat A Saleh
Feb 14, 2016·Current Neurology and Neuroscience Reports·Courtney Lawrence, Jennifer Webb
Mar 12, 2021·Journal of Pediatric Psychology·Reem A TaraziNataly Apollonsky
Jan 17, 2008·Current Opinion in Pediatrics

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.