Hygroscopic dilator (Dilapan-S) and misoprostol combination for the early first-trimester termination of pregnancy: a pilot study

The Journal of Family Planning and Reproductive Health Care
Mannampallil I Samuel, John H Parsons

Abstract

Uptake of the mifepristone/misoprostol combination to induce early medical abortion in England and Wales has been slow. Women's concern that early medical abortion is painful may be a contributory factor. This pilot study evaluated the pain experienced by women when Dilapan-S, a synthetic hygroscopic dilator (polyacrylonitrile) is used instead of mifepristone as cervical preparation prior to administration of a misoprostol. Of 25 patients completing the trial, 17 aborted in a median of 6 hours with an interquartile range of 4.5-11.5 hours. Of these, 15 patients recorded mild discomfort only, 14 considered the procedure excellent and three good. This study suggests that the Dilapan-S/misoprostol combination reduces the pain associated with early medical abortion. Further investigation of the protocol is merited.

References

May 1, 1998·The New England Journal of Medicine·I M SpitzA Robbins
Nov 28, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·Premila W AshokGillian M M Flett
Jun 20, 2006·Contraception·Gillian Penney
Feb 17, 2007·Contraception·Stephanie B TealCarolyn Westhoff

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Citations

Feb 1, 2015·BMC Public Health·Fang YuanZhanchun Feng
Oct 2, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sergey V BarinovOksana V Lazareva
Apr 28, 2018·Journal of Marital and Family Therapy·Stephen T FifeErin Sullivan

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