Hym1p affects cell cycle progression in Saccharomyces cerevisiae

Current Genetics
Lydia M BogomolnayaMichael Polymenis

Abstract

The Saccharomyces cerevisiae HYM1 gene is conserved among eukaryotes. The mammalian orthologue (called MO25) mediates signaling through the AMP-activated protein kinase and other related kinases, implicated in cell proliferation. In yeast, Hym1p plays a role in cellular morphogenesis and also promotes the daughter cell-specific localization of the Ace2p transcription factor. Here, we report that increased dosage of HYM1 apparently shortens the G1 phase of the cell cycle. In the absence of HYM1 or ACE2, mother and daughter cells divide with the same generation times. Genetic analysis of HYM1, ACE2 and CLN3 mutants suggests that these genes together contribute to the establishment of asynchronous mother-daughter cell divisions, but probably not in a linear pathway. Our overall data suggest that Hym1p has a regulatory role in cell cycle progression.

References

Aug 4, 1998·The EMBO Journal·D D HallW Heideman
Jul 26, 2002·Nature·Guri GiaeverMark Johnston
Aug 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Tracy L LaabsWarren Heideman
Nov 18, 2003·Annual Review of Genetics·Daniel J Lew, Daniel J Burke
Dec 3, 2003·Molecular Genetics and Genomics : MGG·B A BryanM Polymenis
Jan 20, 2004·Nature Structural & Molecular Biology·Christine C MilburnDaan M F van Aalten

❮ Previous
Next ❯

Citations

Mar 23, 2006·Current Genetics·Lydia M BogomolnayaMichael Polymenis
Oct 10, 2008·Molecular Biology of the Cell·Cornelia KurischkoFrancis C Luca
Apr 12, 2008·PLoS Genetics·Heidi M BlankMichael Polymenis
May 4, 2005·Yeast
Oct 6, 2005·The Biochemical Journal·Karin ElbingMartin C Schmidt
Aug 31, 2013·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Zhenzhen ZhangMin Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Batten Disease

Batten Disease is a group of nervous system disorders known as neuronal ceroid lipofuscinosis. This feed focuses on neurobiological and neuropathological aspects of this disease.