Hymenolepis diminuta: effects of amoscanate on energy metabolism and ultrastructure

Experimental Parasitology
N F Nelson, H J Saz

Abstract

Amoscanate possesses chemotherapeutic activity against schistosomes, and in higher doses against many other helminths including filariids and Hymenolepis diminuta. The primary mode of action of this compound is unknown. Effects of the drug on the carbohydrate metabolism as well as on the tegumental and nephridial epithelia of H. diminuta were examined. At various time intervals after administration of the drug to rats infected with H. diminuta, the parasites were recovered and incubated in glucose-salts medium for 90 min. Chemotherapy resulted in decreases in succinate, lactate, and acetate recoveries, while ATP levels dropped. In addition, glycogen levels were depressed in drug-treated worms which were homogenized immediately upon isolation. Glycogen synthase I activity was inhibited 16-61% in cestodes obtained from Amoscanate-treated animals and homogenized immediately, but returned to normal levels after incubation for 90 min in glucose-salts medium prior to homogenization and assay. Phosphorylase a activity was found to be 25-30% higher in preparations of worms from drug-treated rats, which correlates with the rapid depletion of glycogen in parasites exposed to the drug. However, in contrast with glycogen synthase activity,...Continue Reading

References

May 1, 1977·The American Journal of Tropical Medicine and Hygiene·H J SazE Bueding
Sep 1, 1981·The American Journal of Tropical Medicine and Hygiene·H G Sen, B N Deb
Sep 1, 1961·Experimental Parasitology·D FAIRBAIRNE L SCHILLER

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Citations

Feb 1, 1987·International Journal for Parasitology·D P McManus
Feb 1, 1987·International Journal for Parasitology·J I Bruce
Jul 1, 1984·Molecular and Biochemical Parasitology·E Ossikovski, R D Walter
Jan 1, 1985·Molecular and Biochemical Parasitology·R D Walter, E Ossikovski
Jan 1, 1988·Parasitology·L H Chappell

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