Hyper-IgE Syndrome in an Infant

Journal of Cutaneous Medicine and Surgery
Mariah Giberson, Laura Finlayson

Abstract

Hyper-immunoglobulin E syndrome (HIES) is a rare primary immunodeficiency disorder that affects multiple systems. One of the early findings is a papulopustular rash, which has a wide differential diagnosis. The authors report the case of a male newborn diagnosed with HIES. He presented with papulopustular dermatitis on the scalp. The authors also present a review of current theory on the pathophysiology, clinical presentation, and management of HIES. Although HIES is a multisystem disorder, many of the manifestations of HIES may present after the neonatal period. The cutaneous manifestations of HIES are usually present shortly after birth, and the presentation of pustules in a newborn may be one of the reasons a dermatologist would be asked to assess a patient in the neonatal period.

References

Sep 12, 2000·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M D Erlewyn-Lajeunesse
Oct 16, 2002·The Journal of Pediatrics·Sarah L ChamlinIlona J Frieden
Sep 24, 2004·Archives of Dermatology·Cheryl Lee D EbertingMaria L Turner
Apr 26, 2006·Journal of the American Academy of Dermatology·Christine A DeWittStephen P Stone
Mar 25, 2009·European Journal of Pediatrics·Ben Zion GartyNufar Marcus
Nov 17, 2011·Orphanet Journal of Rare Diseases·Aleksandra Szczawinska-PoplonykKarolina Gerreth
Jan 25, 2012·Annals of the New York Academy of Sciences·Kathryn J SowerwineAlexandra F Freeman
Mar 24, 2012·Allergology International : Official Journal of the Japanese Society of Allergology·Yoshiyuki Minegishi, Masako Saito
Mar 13, 2014·Indian Dermatology Online Journal·Yun DangSongmei Geng

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Methods Mentioned

BETA
cesarean section

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