PMID: 799245Dec 22, 1976Paper

Hyper-recombination in dam mutants of Escherichia coli K-12

Molecular & General Genetics : MGG
M G Marinus, E B Konrad


F-prime heterogenotes of dam-3 bacteria segregate F-prime homogenotes at a frequency 30-200 times higher than the isogenic dam+ strain. A hyperrecombination mutant which shows increased recombination between chromosomal duplications was characterized as a dam mutant. The dam-3 allele causes a reduction in linkage of proximal unselected markers in transconjugants and increases the recombination frequency between a pair of closely linked markers. It is concluded that dam mutations confer a hyperrecombination phenotype to the cell.


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Feb 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·A J CLARK, A D MARGULIES
Jul 1, 1950·Journal of Bacteriology·B D DAVIS, E S MINGIOLI

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