Hyperactive putamen in patients with paroxysmal kinesigenic choreoathetosis: a resting-state functional magnetic resonance imaging study

Movement Disorders : Official Journal of the Movement Disorder Society
Bo ZhouDong Zhou

Abstract

Paroxysmal kinesigenic choreoathetosis (PKC) is a rare neurologic disorder characterized by sudden attacks of brief involuntary dyskinetic movement, which are precipitated by voluntary movement. The pathophysiology of PKC remains unclear. The purpose of this study is to localize cerebral functional abnormalities in idiopathic PKC with resting-state functional magnetic resonance imaging (fMRI). From May 2007 to August 2008, seven patients with idiopathic PKC were included. The mean age of onset was 11.7 +/- 3.1 (range, 8-17) years and the mean disease duration was 6.9 +/- 5.1 (range, 1-14) years. Seven subjects of an age- and sex-matched control group were recruited. Interictal brain fMRI was performed in the PKC patients and in the normal controls. Voxel-based analysis was used to characterize the alteration of amplitude of low frequency fluctuation (ALFF) in patients with PKC. Difference between the patient patterns and the control was analyzed with Student t-test. The whole brain analysis indicated that the patient group had significantly increased ALFF in the bilateral putamen (P < 0.005) than normal control. fMRI could be useful to evaluate PKC with negative conventional imaging. It was suggested that abnormal cortico-stria...Continue Reading

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Citations

Mar 28, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·ChunYan LuoHui-Fang Shang
Oct 12, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Wan-Yu HsuYung-Yang Lin
Feb 13, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A MéneretE Roze
Jun 28, 2015·Brain : a Journal of Neurology·Cécile GalleaSabine Meunier
Oct 1, 2017·Human Brain Mapping·Renzo ManaraFabrizio Esposito
Jun 27, 2017·Journal of Clinical Movement Disorders·Debra J Ehrlich, Ruth H Walker
May 12, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Xiao-Jun HuangLi Cao
Oct 23, 2020·Expert Review of Neurotherapeutics·Cécile DelormeEmmanuel Roze
Nov 24, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Wei LiuGuangxiang Chen
Jan 16, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Patrick KratschmerJames E C Jepson

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