PMID: 7545529Sep 1, 1995Paper

Hyperadrenocorticism and food restriction-induced life extension in the rat: evidence for divergent regulation of pituitary proopiomelanocortin RNA and adrenocorticotropic hormone biosynthesis

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
E S HanJ F Nelson

Abstract

The increased diurnal elevation of plasma corticosterone (B) induced by food restriction (FR) may play a role in the life span extension of FR. We investigated whether FR alters adrenocorticotropic hormone (ACTH) and proopiomelanocortin (POMC) mRNA levels in plasma and anterior pituitary (AP), since these molecules both regulate and can be suppressed by B. Measurements were made in 3-month-old male Fischer 344 rats that had been ad libitum (AL) or FR (60% of AL calories) since 6 weeks of age. Plasma B was 2-fold higher in FR rats in the PM samples, but did not differ in AM samples. By contrast, plasma ACTH did not differ in the PM samples of FR and AL rats and was 20% lower in AM samples (p < .05) of FR rats. AP content of ACTH was 50% lower in FR rats in both AM and PM samples (p < .01). In contrast, AP contents of POMC and mRNA, primary transcript, and processing intermediate were not reduced in FR rats, and PM content of POMC primary transcript was elevated in FR rats (p < .05). The reduced pituitary and plasma ACTH of FR rats may be the consequence of their elevated plasma B levels. This study also suggests that factors other than elevated ACTH account for FR-induced hyperadrenocorticism. These results also indicate that PO...Continue Reading

Citations

May 12, 2005·Mechanisms of Ageing and Development·Edward J Masoro
Feb 19, 1998·Experimental Gerontology·E J Masoro
Oct 21, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Naveen SharmaGregory D Cartee
Feb 13, 2016·Frontiers in Endocrinology·Andrea Rodrigues VasconcelosElisa Mitiko Kawamoto
Dec 25, 2012·Frontiers in Neuroendocrinology·Penny A DacksCharles V Mobbs
Feb 25, 2009·Laboratory Animals·I H E KasanenT O Nevalainen
May 19, 2011·Nature Communications·Maria SpolidoroLamberto Maffei
Mar 31, 1998·Environmental Health Perspectives·L T FrameJ E Leakey
Apr 29, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Leah MacDonaldStephen Kent
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·B ChandrasekarG L Freeman
Dec 1, 1995·Aging : Clinical and Experimental Research·E J Masoro
Aug 29, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·D R SellV M Monnier
Aug 29, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·E S HanJ F Nelson

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