Hyperalgesia by low doses of the local anesthetic lidocaine involves cannabinoid signaling: an fMRI study in mice

Pain
Simone C BosshardMarkus Rudin

Abstract

Lidocaine is clinically widely used as a local anesthetic inhibiting propagation of action potentials in peripheral nerve fibers. Correspondingly, the functional magnetic resonance imaging (fMRI) response in mouse brain to peripheral noxious input is largely suppressed by local lidocaine administered at doses used in a clinical setting. We observed, however, that local administration of lidocaine at doses 100 × lower than that used clinically led to a significantly increased sensitivity of mice to noxious forepaw stimulation as revealed by fMRI. This hyperalgesic response could be confirmed by behavioral readouts using the von Frey filament test. The increased sensitivity was found to involve a type 1 cannabinoid (CB(1)) receptor-dependent pathway as global CB(1) knockout mice, as well as wild-type mice pretreated systemically with the CB(1) receptor blocker rimonabant, did not display any hyperalgesic effects after low-dose lidocaine. Additional experiments with nociceptor-specific CB(1) receptor knockout mice indicated an involvement of the CB(1) receptors located on the nociceptors. We conclude that low concentrations of lidocaine leads to a sensitization of the nociceptors through a CB(1) receptor-dependent process. This li...Continue Reading

References

Apr 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S OgawaP Glynn
Apr 1, 1995·The Journal of General Physiology·M E BräuW Vogel
Jun 1, 1997·Journal of Neurophysiology·K D DavisD J Mikulis
Feb 13, 1999·Progress in Neurobiology·M J Millan
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·K L Casey
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·S E JordtD Julius
Sep 12, 2002·European Journal of Pharmacology·Rainer HasenederGerhard Hapfelmeier
May 10, 2003·Cellular and Molecular Life Sciences : CMLS·H HermannV Di Marzo
Mar 17, 2004·Annals of Internal Medicine·Clifford J WoolfUNKNOWN American Physiological Society
Jul 30, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Govind Nair, Timothy Q Duong
Aug 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Mohammed A NassarJohn N Wood
Jun 28, 2005·European Journal of Pain : EJP·A Vania ApkarianJon-Kar Zubieta
Mar 2, 2006·Anesthesiology·Oliver H G Wilder-Smith, Lars Arendt-Nielsen
Mar 7, 2006·European Journal of Pain : EJP·Andreas HessKay Brune
Jun 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Johan LiljaChristian Spenger
Jan 4, 2008·The Journal of Clinical Investigation·Andreas LefflerCarla Nau
Nov 7, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Beatriz FioravantiTodd W Vanderah
May 16, 2009·Pharmacological Reports : PR·Carlos E LeiteFlavia V Thiesen
Jun 19, 2009·NMR in Biomedicine·Christof BaltesMarkus Rudin
Aug 8, 2009·Science·Alejandro J Pernía-AndradeHanns Ulrich Zeilhofer
Mar 10, 2010·NeuroImage·Joanna M AdamczakMathias Hoehn

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Citations

Jan 30, 2016·Scientific Reports·Henning Matthias ReimannThoralf Niendorf
Aug 21, 2020·Anaesthesia and Intensive Care·Natalie AklDavid Sommerfield
May 23, 2018·Disease Models & Mechanisms·Mazen Asaad, Jin Hyung Lee
Sep 10, 2018·Neurochemical Research·María S SistiEnrique L Portiansky

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