Hyperammonemia From Ureaplasma Infection in an Immunocompromised Child

Journal of Pediatric Hematology/oncology
Nicholas PlaconeStephanie H Abrams

Abstract

Idiopathic hyperammonemia is a rare, poorly understood, and often lethal condition that has been described in immunocompromised patients. This report describes an immunocompromised patient with acute myelogenous leukemia who developed persistent hyperammonemia up to 705 µmol/L (normal, 0 to 47 µmol/L) refractory to multiple different therapies. However, after beginning azithromycin and then doxycycline therapy for Ureaplasma species infection, the patient showed immediate and sustained clinical improvement and resolution of ammonia levels. Recognizing disseminated Ureaplasma species infection as a potential cause of idiopathic hyperammonemia, an unexplained, often fatal condition in immunocompromised patients, and empirically treating for this infection could potentially be lifesaving.

References

Nov 1, 1988·The American Journal of Medicine·R B MitchellR Saral
Aug 1, 1997·Acta Paediatrica·C RennerA Schless
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J O ClemmesenP Ott
Apr 18, 2001·The Oncologist·P D King, M C Perry
Dec 10, 2008·Clinical Lymphoma & Myeloma·Jaime Lora-TamayoRamón Pujol
Sep 16, 2014·Journal of Pediatric Hematology/oncology·Shogo KobayashiAtsushi Kikuta
Jan 13, 2015·Journal of Clinical Anesthesia·Roy K Kiberenge, Humphrey Lam
Apr 24, 2015·Science Translational Medicine·Ankit BharatRobin Patel
Sep 4, 2015·Transplantation·Catherine ChenChad A Witt
Nov 1, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·X WangR Patel
Feb 24, 2017·Rinshō shinkeigaku = Clinical neurology·Toshiaki GodaDaisuke Takahashi
May 26, 2017·BMJ Case Reports·Abubaker A I HassanAbdelaziz Mohamed
Jan 24, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Riley GraetzEmmanuel Katsanis

❮ Previous
Next ❯

Citations

Jan 2, 2021·Journal of Microbiological Methods·Derek FlemingRobin Patel
Nov 17, 2020·Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine·Robert F LegerKsenia D Guvakova
Oct 18, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Scott C RobertsMichael G Ison

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
PCR

Related Concepts

Related Feeds

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Transplant Infectious Disease : an Official Journal of the Transplantation Society
Riley GraetzEmmanuel Katsanis
Nihon rinsho. Japanese journal of clinical medicine
S Arashima
© 2022 Meta ULC. All rights reserved