PMID: 8938556Nov 1, 1996Paper

Hyperammonemia-induced depletion of glutamate and branched-chain amino acids in muscle and plasma

Journal of Hepatology
H LewelingE Holm

Abstract

Exogenous hyperammonemia is known to decrease the plasma levels of branched-chain amino acids (BCAA). To investigate whether changes in intracellular amino acid concentrations of muscle are associated with and may, at least in part, mediate this effect, experiments were carried out on a total of 60 male Wistar rats. Five groups were formed in a randomized manner. Group A: no treatment; groups B1 and B2: 2-hour and 6-hour continuous central-venous infusions, respectively, of sodium salts; groups C1 and C2: 2-hour and 6-hour infusions of ammonium salts. We obtained venous blood samples and muscle biopsies. Plasma ammonia, whole blood glucose, serum insulin, blood pH, and amino acids in plasma as well as in the intracellular water of muscle were measured. As compared with control group A, groups C1 and C2 displayed a 3.3- and a 4-fold increase, respectively, in the plasma ammonium concentration. Regarding insulin, the ammonium-infused rats were similar to group A but not to the sodium-infused B groups, which had significantly lower insulin concentrations. Administering ammonium brought about a decline in BCAA concentrations in plasma after 2 hours and in muscle after 6 hours. The ammonium-induced fall in intracellular BCAA values ...Continue Reading

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Feb 1, 2008·Journal of Inherited Metabolic Disease·Claude Bachmann
Mar 31, 2004·Molecular Genetics and Metabolism·Fernando ScagliaBrendan Lee
Jan 6, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C LoguercioC Del Vecchio Blanco
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Aug 16, 2013·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Takumi KawaguchiMichio Sata
Jan 15, 2019·International Journal of Experimental Pathology·Milan Holeček, Melita Vodeničarovová
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Jul 30, 2020·International Journal of Molecular Sciences·Tiffany J Rios-FullerRobert J Schneider
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Jul 31, 2018·Journal of Physiology and Biochemistry·Milan Holeček, Melita Vodeničarovová
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Jan 15, 2013·Metabolic Brain Disease·Gitte DamHendrik Vilstrup
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