Hyperammonemia Syndrome After Lung Transplantation: A Single Center Experience

Transplantation
Catherine ChenChad A Witt

Abstract

Hyperammonemia is a rare, often fatal complication after transplantation. The etiology is unknown, but recognition and rapid treatment may help to improve the survival of this unusual syndrome. We present the largest case series to date of hyperammonemia after lung transplantation (LTx) and discuss a treatment protocol that has been developed at our institution. We conducted a retrospective cohort series of patients who underwent LTx between January 1, 2000, and December 31, 2013. Patients who developed hyperammonemia syndrome in the posttransplantation period, which was defined as symptoms of encephalopathy and plasma ammonia level exceeding 200 μmol/L on at least 1 occasion, were included. Data including demographics, antimicrobial and immunosuppression regimens, ammonia levels and other pertinent laboratory data, treatments administered, and outcomes were recorded. Eight of 807 lung transplant recipients developed hyperammonemia syndrome postoperatively during this time period. Median time to onset was 9.0 days, and median peak ammonia level was 370 μmol/L. All 8 patients were treated with hemodialysis, 7 of 8 patients were treated with bowel decontamination, and 5 of 8 patients were treated with nitrogen scavenging agents. ...Continue Reading

References

Oct 1, 1991·American Journal of Hematology·N TseJ A Glaspy
Apr 1, 1984·Neurochemical Research·J E O'ConnorS Grisolía
Jan 1, 1997·Gastroenterology·G R LichtensteinG T Berry
Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G TherrienR F Butterworth
Oct 6, 1997·Annals of Internal Medicine·M TuchmanG T Berry
Jun 20, 1998·Annals of Internal Medicine·J F RuedaD C Brennan
Feb 19, 2000·Annals of Internal Medicine·G R LichtensteinG T Berry
Oct 23, 2003·Digestive Diseases·Mariano MalaguarneraGiovanni Pennisi
Oct 18, 2005·Critical Care Clinics·Brendan LeeMarshall L Summar
Jan 26, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S NurmohamedF Bemelman
Jun 1, 2007·The New England Journal of Medicine·Gregory M EnnsAda Hamosh
Oct 16, 2007·Chest·Alison S Clay, Bryan E Hainline
Jun 28, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Susan D Moffatt-BrucePatrick Ross
Sep 7, 2011·Neurology·Sara HockerEelco F M Wijdicks
May 31, 2012·Orphanet Journal of Rare Diseases·Johannes HäberleCarlo Dionisi-Vici
Aug 28, 2012·Metabolism: Clinical and Experimental·Maria M AdevaCristóbal Donapetry
Sep 4, 2013·Hemodialysis International·Siddiq AnwarDaniel C Brennan
Nov 19, 2013·Nature Medicine·Vinita Rangroo ThraneMaiken Nedergaard
Dec 10, 2013·Lancet·Mark E WylamJohn P Scott
Jan 13, 2015·Journal of Clinical Anesthesia·Roy K Kiberenge, Humphrey Lam
Apr 24, 2015·Science Translational Medicine·Ankit BharatRobin Patel

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Citations

Nov 1, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·X WangR Patel
Dec 8, 2016·American Journal of Respiratory and Critical Care Medicine·Ramiro FernandezAnkit Bharat
Jul 10, 2018·Critical Care Medicine·Amra SakusicOgnjen Gajic
Feb 23, 2019·Journal of Pediatric Hematology/oncology·Nicholas PlaconeStephanie H Abrams
Apr 20, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Chase A CannonRobert M Rakita
Jun 20, 2018·Drugs·Steven IvulichGregory Snell
Nov 17, 2016·International Journal of Hepatology·Abidullah KhanWazir Mohammad Khan
Oct 28, 2020·Expert Review of Respiratory Medicine·Lorena van den BogaartOriol Manuel
Nov 13, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Bruno F BuzoWendy I Sligl
Feb 19, 2020·Transplantation Proceedings·Akshay KumarGyanshankar Mishra
Nov 17, 2020·Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine·Robert F LegerKsenia D Guvakova
Oct 18, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Scott C RobertsMichael G Ison
Jul 3, 2018·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Diane C McLaughlinLauren K Ng
Jan 10, 2021·The Annals of Thoracic Surgery·Patrick G ChanPablo G Sanchez
Jun 15, 2021·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Vanessa SoetantoHarpreet Singh Grewal
Aug 28, 2021·World Journal of Transplantation·Metodija SekulovskiTsvetelina Velikova

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