PMID: 3215846Dec 1, 1988Paper

Hyperammoniemia during prolonged exercise: an effect of glycogen depletion?

Journal of Applied Physiology
S Broberg, K Sahlin

Abstract

Eight healthy men exercised to exhaustion on a cycle ergometer at a work load of 176 +/- 9 (SE) W corresponding to 67% (range 63-69%) of their maximal O2 uptake (exercise I). Exercise of the same work load was repeated after 75 min of recovery (exercise II). Exercise duration (range) was 65 (50-90) and 21 (14-30) min for exercise I and II, respectively. Femoral venous blood samples were obtained before and during exercise and analyzed for NH3 and lactate. Plasma NH3 was 12 +/- 2 and 19 +/- 6 mumol/l before exercise I and II, respectively and increased during exercise to exhaustion to peak values of 195 +/- 29 (exercise I) and 250 +/- 30 (exercise II) mumol/l, respectively. Plasma NH3 increased faster during exercise II compared with exercise I and at the end of exercise II was threefold higher than the value for the corresponding time of exercise I (P less than 0.001). Blood lactate increased during exercise I and after 20 min of exercise was 3.7 +/- 0.4 mmol/l and remained unchanged until exhaustion. During exercise II blood lactate increased less than during exercise I. It is concluded that long-term exercise to exhaustion results in large increases in plasma NH3 despite relatively low levels of blood lactate. It is suggested...Continue Reading

Citations

Nov 28, 2002·Scandinavian Journal of Medicine & Science in Sports·Y YuanK M Chan
Jan 1, 1992·European Journal of Applied Physiology and Occupational Physiology·D A Sewell, R C Harris
Apr 7, 2007·Bulletin of Experimental Biology and Medicine·M V OsikovL V Krivokhizhina
Apr 3, 2020·Journal of Applied Physiology·Annette BellarSrinivasan Dasarathy
Jan 1, 1992·European Journal of Applied Physiology and Occupational Physiology·A Urhausen, W Kindermann
Jan 1, 1991·European Journal of Applied Physiology and Occupational Physiology·H Itoh, T Ohkuwa
Jan 1, 1995·European Journal of Applied Physiology and Occupational Physiology·D CzarnowskiJ Górski
Jul 13, 2012·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Neeta MehtaHarry V Precheur
Jan 1, 1993·European Journal of Applied Physiology and Occupational Physiology·J A ZoladzA Zychowski
Jan 1, 1991·European Journal of Applied Physiology and Occupational Physiology·P L GreenhaffR J Maughan
Jan 17, 2012·British Journal of Clinical Pharmacology·Geltrude MingroneKatherine Macé
Jul 20, 2000·Clinical and Experimental Pharmacology & Physiology·K OginoC Shigemasa
Aug 1, 1990·The American Journal of Physiology·T E GrahamB Saltin

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