Hyperamylasaemia and acute pancreatitis in paracetamol poisoning

Alimentary Pharmacology & Therapeutics
L E Schmidt, Kim Dalhoff

Abstract

Hyperamylasaemia and even acute pancreatitis have been reported in patients with paracetamol poisoning. To describe the incidence, clinical characteristics, and prognostic implications of hyperamylasaemia in paracetamol poisoning. Six hundred and two patients transferred to a specialized unit with severe paracetamol poisoning and 212 unselected patients admitted from the local region. Retrospective study based on hospital charts. The optimum threshold of serum amylase to discriminate non-survivors was identified. An elevated serum amylase (>100 U/L) occurred in 28 of the unselected patients (13%), in 218 of the transferred patients (36%), and in 118 of 148 patients (80%) with fulminant hepatic failure. Only 33 cases of paracetamol-associated acute pancreatitis were diagnosed. A threshold serum amylase of 150 U/L to discriminate non-survivors had sensitivity 76%, specificity 85%, positive predictive value 33%, and negative predictive value 97%. In a logistic regression analysis, a serum amylase > 150 U/L was associated with an excess mortality (odds ratio 5.0, 2.6-9.7). Hyperamylasaemia is frequent in patients with paracetamol poisoning, whereas clinical acute pancreatitis occurs rarely. The incidence of hyperamylasaemia increas...Continue Reading

References

Jun 1, 1978·Postgraduate Medical Journal·A N HamlynO James
Mar 19, 1977·British Medical Journal·I T Gilmore, E Tourvas
Apr 23, 1977·British Medical Journal·R A Coward
Jan 1, 1991·Journal of Toxicology. Clinical Toxicology·H C MofensonG Steckler
Feb 1, 1990·Journal of Clinical Gastroenterology·S V SastriJ B Marshall
Dec 1, 1991·Journal of Clinical Gastroenterology·J BinekM Heer
Jul 1, 1985·Critical Care Medicine·D W WeaverR F Wilson
Aug 1, 1989·Gastroenterology·J G O'GradyR Williams
May 1, 1985·Mayo Clinic Proceedings·J RakelaW P Baldus
Dec 1, 1973·The American Journal of Digestive Diseases·J M Ham, P Fitzpatrick
Feb 1, 1982·Digestive Diseases and Sciences·J E Fischer
Jan 1, 1981·Gastroenterologia Japonica·S G Tewari Sibghatullah
Mar 1, 1997·QJM : Monthly Journal of the Association of Physicians·A L Jones, L F Prescott
Nov 11, 1998·Journal of the American College of Surgeons·P C KuoL B Johnson
Nov 9, 2001·European Journal of Clinical Pharmacology·V AndersenM Andersen
Mar 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lars E SchmidtHenrik Enghusen Poulsen
May 8, 2002·British Journal of Clinical Pharmacology·Lars E Schmidt, Kim Dalhoff

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Citations

Feb 14, 2016·Cancer Medicine·Milica StefanovićMatthias Löhr
Oct 9, 2013·Clinics in Liver Disease·Chalermrat Bunchorntavakul, K Rajender Reddy
Jun 9, 2016·Open Access Macedonian Journal of Medical Sciences·Irena KasmiGentian Kasmi
Jan 18, 2011·European Journal of Internal Medicine·Dorota Ksiądzyna
Mar 29, 2006·Clinics in Laboratory Medicine·Adam K RowdenMark A Kirk
Jan 27, 2009·The Mount Sinai Journal of Medicine, New York·Hui-Hui TanPaul Martin
Oct 18, 2005·The Medical Clinics of North America·Adam K RowdenMark A Kirk
Nov 2, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Julian KrauskopfJos C Kleinjans
Apr 22, 2017·The Cochrane Database of Systematic Reviews·Gianluca RompianesiKurinchi Selvan Gurusamy
Feb 19, 2009·The American Journal of Gastroenterology·Gregory A CotéUNKNOWN Acute Liver Failure Study Group
Sep 14, 2018·World Journal of Clinical Cases·Ya-Hong HeHua-Ming Li

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