Hyperandrogenism sensitizes leukocytes to hyperglycemia to promote oxidative stress in lean reproductive-age women.

The Journal of Clinical Endocrinology and Metabolism
Frank GonzálezHilary E Blair

Abstract

Hyperandrogenism and oxidative stress are related in polycystic ovary syndrome (PCOS), but it is unknown whether hyperandrogenemia can activate oxidative stress. The purpose of this study was to determine the effect of oral androgen administration on fasting and glucose-stimulated leukocytic reactive oxygen species (ROS) generation, reduced nicotinamide adenine dinucleotide phosphate oxidase p47(phox) subunit gene expression, and plasma thiobarbituric acid-reactive substances (TBARS) in lean healthy reproductive-age women. Sixteen lean healthy ovulatory reproductive-age women were treated with 130 mg dehydroepiandrosterone (DHEA) or placebo (n = 8 each) for 5 d in this randomized, controlled, double-blind study that was performed at an an academic medical center. Leukocytic ROS generation, p47(phox) gene expression, and plasma TBARS were quantified in the fasting state and 2 h after glucose ingestion, before and after treatment. Before treatment, subjects receiving DHEA or placebo exhibited no differences in androgens or any prooxidant markers while fasting and after glucose ingestion. Compared with placebo, DHEA administration raised levels of testosterone, androstenedione, and DHEA-sulfate, increased the percent change in glu...Continue Reading

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Citations

Dec 20, 2012·American Journal of Physiology. Endocrinology and Metabolism·Frank GonzálezJudi Minium
Dec 4, 2012·Fertility and Sterility·Georgios BoutziosEvanthia Diamanti-Kandarakis
Nov 21, 2013·The Journal of Sexual Medicine·Víctor M VictorAntonio Hernández-Mijares
Jan 16, 2016·Oxidative Medicine and Cellular Longevity·Tao ZuoWenming Xu
Feb 21, 2013·Molecular and Cellular Endocrinology·María InsenserHéctor F Escobar-Morreale
Sep 30, 2016·European Journal of Endocrinology·Evanthia Diamanti-KandarakisGeorgia Kassi
Dec 19, 2016·Trends in Endocrinology and Metabolism : TEM·Stefano PalombaGiovanni Battista La Sala
Nov 9, 2016·Reproductive Sciences·Julio ÁvilaAngela Palumbo
Mar 10, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hamidreza JamilianZatollah Asemi
Feb 12, 2014·The Journal of Clinical Endocrinology and Metabolism·Frank GonzálezHilary E Blair
Mar 25, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Rheure Alves Moreira LopesRita C Tostes
Feb 26, 2015·American Journal of Physiology. Endocrinology and Metabolism·Steven K MalinFrank González
Jul 13, 2019·The Journal of Clinical Endocrinology and Metabolism·Frank GonzálezAnthony J Acton
Jun 24, 2017·Frontiers in Pharmacology·Maria A SortinoFilippo Drago
Apr 25, 2018·Journal of Endocrinological Investigation·M CalzadaA M Torres
Nov 6, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rita C TostesJane F Reckelhoff
Sep 12, 2020·Reproductive Sciences·Hannah E Young, Wendy E Ward
Oct 10, 2020·Fertility and Sterility·Francesca IannantuoniVíctor Manuel Víctor

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