Hyperbaric oxygen: a means of decreasing ischemic epiphyseal damage in a pediatric rabbit model

The Journal of Hand Surgery
D D WeissH S Matloub

Abstract

The effect of hyperbaric oxygen on epiphyseal ischemia was evaluated using a pediatric rabbit model. Forty-five animals were compared in this study: 23 from a control pilot study and 22 hyperbaric exposed animals. In each animal the right distal femoral and proximal tibial epiphyses were isolated on a popliteal vascular pedicle. The left leg acted as the control. The growth difference between the rabbit's hindlimbs was the means of comparison throughout the groups established. Warm ischemia was induced by applying a vascular clamp to the right popliteal artery for 12 hours (20 animals) and 7 hours (17 animals). The remaining 8 animals underwent a sham operation without interruption of epiphyseal perfusion. On completion of the ischemic period hyperbaric oxygen therapy (HBOT) was performed on 12 12-hour (12h-HBOT) and 10 7-hour (7h-HBOT) animals at 2 atmospheres for 90 minutes twice per day for 4 postoperative days. The animals were killed on either postoperative day 14 or 90. Measurement of longitudinal bone growth was performed on the 90-day animals from serial radiographs at the time of surgery and then at 1 month, 2 months, and 3 months after surgery. There was no significant difference in longitudinal bone growth between th...Continue Reading

References

Jan 1, 1991·Microsurgery·J S TarasR D Fitch
Nov 1, 1991·Plastic and Reconstructive Surgery·E P KindwallD L Larson
May 1, 1990·Archives of Surgery·C M KaelinJ E Hoopes
Jan 17, 1985·The New England Journal of Medicine·J M McCord
Apr 1, 1988·The Journal of Trauma·R M Zuker, J H Stevenson
Mar 1, 1987·The Journal of Hand Surgery·J A NunleyJ R Urbaniak
Jan 1, 1987·Plastic and Reconstructive Surgery·G NylanderJ Larsson
Jan 1, 1987·The Journal of Hand Surgery·R H StarkK Lynch
Apr 1, 1985·Archives of Disease in Childhood·E RosenthalV Bialik
Oct 1, 1985·Plastic and Reconstructive Surgery·G NylanderJ Larsson
Jan 1, 1984·Plastic and Reconstructive Surgery·C M TanJ E Hoopes
Jan 1, 1984·Microsurgery·R H StarkH S Matloub
Mar 1, 1995·Journal of Reconstructive Microsurgery·E DemiriJ Baudet
Oct 1, 1996·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·D M StevensD A Bianchi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS
Christopher J SalgadoRaoul Gonzales
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
D M StevensD A Bianchi
© 2021 Meta ULC. All rights reserved