PMID: 9422576Jan 9, 1998Paper

Hyperbaric oxygen and basic fibroblast growth factor promote growth of irradiated bone

International Journal of Radiation Oncology, Biology, Physics
X WangP Okunieff

Abstract

The goal of the current experiment is to test for protective effect of hyperbaric oxygen (HBO) and basic fibroblast growth factor (bFGF) on bone growth. Control C3H mice received hind leg irradiation at 0, 10, 20, or 30 Gy. HBO-treated groups received radiation 1, 5, or 9 weeks before beginning HBO. The remaining groups began bFGF +/- HBO 1 or 5 weeks after 30 Gy. HBO treatments were given 5 days per week for 4 weeks at 2 ATA for 3 h/day. bFGF was given intravenously at 6 microg twice a week for 4 weeks. HBO improved bone growth after radiation in the 10 and 20 Gy groups. At 18 weeks control tibia length discrepancy is 0.0, 4.2, 8.2, and 10.7% after 0, 10, 20, and 30 Gy, respectively. HBO beginning in week 1, 5, or 9 following 10 Gy decreased these discrepancies to 2.0% (p < 0.05), 1.8% (p < 0.05), and 2.4% (p < 0.05), respectively. After 20 Gy, HBO decreased these discrepancies to 7.0% (p = ns), 4.9% (p < 0.05), and 3.6% (p < 0.05), respectively. At 30 Gy, HBO alone had no effect on bone shortening. bFGF improved tibia length discrepancy with or without HBO. At 18 weeks length discrepancies were 6.5% (p < 0.05) and 7.3 (p < 0.05), and after bFGF alone were 6.8% (p < 0.05) and 7.3% (p < 0.05) for treatment beginning in week 1 o...Continue Reading

References

May 1, 1978·International Journal of Radiation Oncology, Biology, Physics·K H LukC F Fellows
Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K M ZseboI K McNiece
Dec 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H SuitJ T Efird
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·H D Suit
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·M Urano, Y Abe
Aug 1, 1991·International Journal of Radiation Oncology, Biology, Physics·P OkunieffL J Neuringer
Aug 1, 1990·International Journal of Radiation Oncology, Biology, Physics·M W DionB Anderson
Feb 1, 1989·International Journal of Radiation Oncology, Biology, Physics·F M UckunC W Song
Jan 1, 1989·Connective Tissue Research·S B RodanG A Rodan
Jul 1, 1989·International Journal of Radiation Oncology, Biology, Physics·M W DionJ W Osborne
May 1, 1988·The Journal of Clinical Investigation·E CanalisT McCarthy
May 1, 1982·International Journal of Radiation Oncology, Biology, Physics·E L TravisT N Padikal
May 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J J FeldmeierR Alecu
Oct 15, 1994·International Journal of Radiation Oncology, Biology, Physics·M S AnscherR L Jirtle
Jul 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S DelanianM Housset
May 1, 1996·International Journal of Radiation Oncology, Biology, Physics·J L LefaixF Daburon

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