Hyperbaric oxygen as an adjuvant to temozolomide nanoparticle inhibits glioma growth by inducing G2/M phase arrest

Nanomedicine
Yuanyuan XieXiangliang Yang

Abstract

To study the effects of combinational treatment of hyperbaric oxygen (HBO) and nanotemozolomide in glioma. Temozolomide (TMZ)-loaded porous silicon nanoparticles (TMZ/PSi NPs) were prepared. In vitro and in vivo evaluations were performed. The cell uptake of TMZ/PSi NPs could be tracked by autofluorescence of porous silicon. The concentration of oxygen in tumor was improved and the antitumor rate was increased to 84.2% in the TMZ/PSi NPs combined with HBO group. The viability of hypoxia-induced glioma C6 cells was decreased and cell cycle was arrested at G2/M phase in response to TMZ/PSi NPs treatment with HBO compared with continuous treatment with hypoxia. The combinational treatment of TMZ/PSi NPs and HBO could be a promising therapeutic strategy for glioma.

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Citations

Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shalini Sundramurthi ChelliahIshwar Parhar

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Methods Mentioned

BETA
transmission electron microscopy
dynamic light scattering
confocal microscopy
flow cytometry
fluorescence-activated cell sorting

Software Mentioned

CXP

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