Hyperbaric oxygen-generating hydrogels

Biomaterials
Sujin Park, Kyung Min Park

Abstract

Oxygen plays a critical role as a substrate for metabolism and as a signaling molecule regulating cellular activities. In particular, hyperbaric oxygen has been demonstrated to facilitate wound healing processes, including cell proliferative activity, tissue growth, and vascular recruitment, via transient oxidative stress in surrounding tissues. In this study, we report hyperbaric oxygen-generating (HOG) hydrogels comprising thiolated gelatin (GtnSH) that can form hydrogel networks in situ via a calcium peroxide-mediated oxidative cross-linking reaction with oxygen generation. We demonstrate that the HOG hydrogels rapidly generate molecular oxygen up to hyperoxic levels and maintain hyperoxic levels for up to 12 days in vitro and 4 h in vivo. The HOG hydrogel enhances cell proliferative activities of human dermal fibroblasts and endothelial cells, which are closely related to wound healing and angiogenesis. Moreover, the HOG hydrogel promotes wound healing with enhanced tissue infiltration and vascular recruitment in vivo. The HOG hydrogels is a new type of oxygen-generating biomaterials that have great potential as advanced hydrogel materials for tissue regenerative medicine applications, including the treatment of wound and v...Continue Reading

Citations

May 13, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Andisheh Motealleh, Nermin S Kehr
Jun 13, 2020·Frontiers in Bioengineering and Biotechnology·Tai-En HsiehChieh-Cheng Huang
Dec 4, 2019·Science China. Life Sciences·Shutao GaoJinchao Zhang
Nov 17, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Phuong Le ThiKi Dong Park
Jan 21, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jeon Il Kang, Kyung Min Park
Jan 14, 2021·Advanced Science·Hui HuYuehua Li
Feb 20, 2021·Trends in Biotechnology·Niels G A WillemenJeroen Leijten
Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Tarun AgarwalTapas Kumar Maiti
May 15, 2021·Chemical Communications : Chem Comm·Daisuke TomiokaMichiya Matsusaki
Jul 5, 2019·Biomacromolecules·Nureddin AshammakhiAli Khademhosseini
Dec 23, 2021·ACS Applied Materials & Interfaces·Pingping XuWeizhi Liu

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