Hyperbaric Oxygen Reduces Infarction Volume and Hemorrhagic Transformation Through ATP/NAD+ /Sirt1 Pathway in Hyperglycemic Middle Cerebral Artery Occlusion Rats

Stroke; a Journal of Cerebral Circulation
Qin HuJohn H Zhang

Abstract

Energy depletion is a critical factor leading to cell death and brain dysfunction after ischemic stroke. In this study, we investigated whether energy depletion is involved in hyperglycemia-induced hemorrhagic transformation after ischemic stroke and determined the pathway underlying the beneficial effects of hyperbaric oxygen (HBO). After 2-hour middle cerebral artery occlusion, hyperglycemia was induced by injecting 50% dextrose (6 mL/kg) intraperitoneally at the onset of reperfusion. Immediately after it, rats were exposed to HBO at 2 atmospheres absolutes for 1 hour. ATP synthase inhibitor oligomycin A, nicotinamide phosphoribosyl transferase inhibitor FK866, or silent mating type information regulation 2 homolog 1 siRNA was administrated for interventions. Infarct volume, hemorrhagic volume, and neurobehavioral deficits were recorded; the level of blood glucose, ATP, and nicotinamide adenine dinucleotide and the activity of nicotinamide phosphoribosyl transferase were monitored; the expression of silent mating type information regulation 2 homolog 1, acetylated p53, acetylated nuclear factor-κB, and cleaved caspase 3 were detected by Western blots; and the activity of matrix metalloproteinase-9 was assayed by zymography. H...Continue Reading

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Citations

Aug 2, 2018·Journal of Cellular Physiology·Sara NiksereshtAbolhassan Ahmadiani
Mar 11, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zhenhua ZhouJohn H Zhang
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Oct 22, 2020·Oxidative Medicine and Cellular Longevity·Dengwen ZhangZhengyuan Xia
Jan 2, 2021·International Journal of Environmental Research and Public Health·Daniela CevolaniMartino Cellerini
Apr 1, 2021·Rejuvenation Research·Shraddha M KamatJames W Larrick
May 9, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nannan LiuGuanhua Du
Jul 10, 2021·Journal of Neurochemistry·Shuiqiao LiuYingfei Wang

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