Hyperbaric oxygen reduces ischemia-induced skeletal muscle injury

Plastic and Reconstructive Surgery
T HaapaniemiJ Larsson

Abstract

The effect of hyperbaric oxygen treatment on skeletal muscle submitted to 3 or 4 hours of ischemia was studied in a rat hindlimb model after 48 hours of reperfusion. Forty-eight male Sprague-Dawley rats were allocated to four groups. In the two treatment groups, hyperbaric oxygen was given for 45 minutes at 2.2 atm immediately and 4,8,16,24,32, and 40 hours after release of the ischemia-inducing tourniquet. The injury to skeletal muscle was quantified from the uptake of 99mtechnetium-pyrophosphate (injected intravenously after 45 hours of reperfusion) in anterior tibial muscle harvested 3 hours later. The uptake was significantly lower in hyperbaric oxygen-treated rats than in untreated rats with 3 or 4 hours of ischemia (p < 0.01 and P < 0.05). After 4 hours of ischemia, the changes in levels of the intracellular muscle compounds adenosine triphosphate, phosphocreatine, and lactate were less in the hyperbaric oxygen-treated rats than in the untreated animals.

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Citations

Oct 9, 2002·Journal of the Peripheral Nervous System : JPNS·Fajko F BajrovićIgor B Mekjavić
Jul 23, 2011·The Journal of Surgical Research·Xiaoyu K ChenThomas J Walters
Apr 13, 2011·Injury·Syed GillaniDavid J Hak
Sep 22, 2009·Burns : Journal of the International Society for Burn Injuries·Tayfun TürkaslanZafer Ozsoy
Mar 17, 1998·Experimental Neurology·T HaapaniemiL Dahlin
Nov 14, 2006·Plastic and Reconstructive Surgery·Neal Handel
Jun 20, 1996·The New England Journal of Medicine·P M Tibbles, J S Edelsberg
Sep 25, 1999·The American Journal of Sports Medicine·J R StaplesD C McKenzie
Apr 9, 2001·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·T HaapaniemiL B Dahlin
Dec 24, 2002·Microsurgery·Flavia S PradaArnaldo V Zumiotti
Aug 14, 1998·Plastic and Reconstructive Surgery·Y RamonI J Peled
Aug 2, 2006·Clinical and Experimental Dermatology·S EfratiN Gall
Jun 26, 2003·Clinical and Experimental Pharmacology & Physiology·Alessia PedotoEnrico M Camporesi

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