Hyperbaric oxygen solution infused into the anterior interventricular vein at reperfusion reduces infarct size in swine

American Journal of Physiology. Heart and Circulatory Physiology
Lynne L JohnsonDavid O Williams

Abstract

This study was designed to test the hypothesis that raising myocardial O2 via diffusion of a hyperbaric oxygen solution (AO) administered through the anterior interventricular vein (AIV) will reduce infarct size by reducing reperfusion injury associated with reduced neutrophil activation. In three pilot open-chest swine experiments, myocardial tissue Po2 was monitored using an oxygen probe during coronary occlusion (Occl) and reperfusion (Rep). One control experiment had no AIV infusion; a second control received arterial blood drawn from the femoral artery infused into the AIV during Rep. In a third open-chest experiment, AO mixed with arterial blood was infused through the AIV at Rep. In controls, tissue Po2 in the risk region (RR) rose early in Rep and then fell to Occl levels, whereas in AO-treated animals, myocardial Po2 remained above baseline. The following three groups of five swine then underwent 60 min of left anterior descending coronary artery Occl and Rep: 1) arterial blood infused at Rep as controls (Con), 2) AO infused beginning 30 min after Rep (AO 30 min), and 3) AO infused immediately at Rep (AO 0 min). There were no differences among the three groups in hemodynamics or myocardial blood flow during baseline (B...Continue Reading

References

Jan 1, 1991·Free Radical Biology & Medicine·S R Thom, M E Elbuken
Jul 1, 1991·Journal of the American College of Cardiology·F D KolodgieA Farb
May 1, 1990·Journal of Pharmacological Methods·C SchierwagenC Lundberg
Aug 1, 1986·The American Journal of Physiology·R L EnglerG W Schmid-Schönbein
Jul 1, 1966·Circulation Research·A KrugG Korb
Feb 1, 1993·Journal of the American College of Cardiology·R A Kloner
Mar 1, 1997·The American Journal of Physiology·S R ThomL Kilpatrick
Oct 10, 1997·The American Journal of Physiology·L S Ritter, P F McDonagh
Nov 5, 1997·American Heart Journal·A H ShandlingY Stavitsky
Mar 21, 2000·International Anesthesiology Clinics·J Buras
Dec 6, 2003·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·J Richard SpearsRichard vander Heide

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Citations

Jun 19, 2007·Antioxidants & Redox Signaling·Vijay Kumar KutalaPeriannan Kuppusamy
Aug 14, 2009·Clinical and Experimental Pharmacology & Physiology·Leonardo dos SantosPaulo J F Tucci
Jul 9, 2014·Pharmacology & Therapeutics·Giacinta GuariniMario Marzilli
Dec 3, 2016·Expert Review of Respiratory Medicine·Jonathan A GehlbachIra M Cheifetz

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