Hyperbaric oxygen therapy attenuates central sensitization induced by a thermal injury in humans

Acta Anaesthesiologica Scandinavica
V M RasmussenM U Werner

Abstract

Hyperbaric oxygen (HBO2 ) treatment has in animal experiments demonstrated antinociceptive effects. It was hypothesized that these effects would attenuate secondary hyperalgesia areas (SHAs), an expression of central sensitization, after a first-degree thermal injury in humans. Seventeen healthy volunteers were examined during two sessions using a randomized crossover design. Volunteers were studied during control conditions (ambient pressure, FI O2  = 0.21) and during HBO2 (2.4 standard atmosphere, FI O2  = 1.0, 90 min) conditions in a pressure chamber. Quantitative sensory testing, including assessment of SHAs was performed. A statistically significant overall attenuation of SHAs was seen during the HBO2 sessions compared with the control-sessions (P = 0.011). In the eight volunteers starting with the HBO2 session, no difference in SHAs compared with control was demonstrated. However, in the nine volunteers starting with the control session, a statistical significant attenuation of SHAs was demonstrated in the HBO2 session (P = 0.004). The results indicate that HBO2 therapy in humans attenuates central sensitization induced by a thermal skin injury, compared with control. These new and original findings in humans corroborate ...Continue Reading

References

Aug 1, 1991·Burns : Journal of the International Society for Burn Injuries·C HammarlundP Svedman
Feb 1, 1991·Burns : Journal of the International Society for Burn Injuries·C SvedmanP Svedman
Jan 27, 1990·BMJ : British Medical Journal·J N MatthewsP Royston
Mar 10, 1990·BMJ : British Medical Journal·S Senn
May 1, 1997·Plastic and Reconstructive Surgery·J A NiezgodaA B Storrow
Jul 17, 1998·Anesthesiology·J L PedersenH Kehlet
Mar 11, 1999·Anesthesia and Analgesia·K F SjölundA Sollevi
Mar 10, 2000·Documenta Ophthalmologica. Advances in Ophthalmology·E M VingoloE Rispoli
Sep 19, 2000·British Journal of Anaesthesia·J LillesøH Kehlet
Jul 21, 2001·Regional Anesthesia and Pain Medicine·M U WernerH Kehlet
Dec 1, 2001·European Journal of Pharmacology·G SümenL Eroglu
Feb 1, 2002·European Journal of Applied Physiology·P GregorevicD A Williams
May 23, 2002·Regional Anesthesia and Pain Medicine·Mads U WernerHenrik Kehlet
Jul 20, 2002·Anesthesiology·Jesper DirksJørgen B Dahl
Oct 25, 2003·Anesthesiology·Mads U WernerHenrik Kehlet
Jul 22, 2005·The Cochrane Database of Systematic Reviews·M H BennettC Milross
Sep 2, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Huang NieZhenghua Zhu
Jun 17, 2006·Burns : Journal of the International Society for Burn Injuries·Jason WasiakHeather J Cleland
Aug 4, 2006·The Journal of Pain : Official Journal of the American Pain Society·Ole MathiesenJorgen B Dahl
Nov 23, 2006·The Journal of Pain : Official Journal of the American Pain Society·Adam R FrymoyerKarin Lottrup Petersen
Aug 4, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Enzo Maria VingoloPaolo Pelaia
Aug 11, 2007·The Journal of Pain : Official Journal of the American Pain Society·Hilary D WilsonPerry N Fuchs
Feb 29, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J W Bartlett, C Frost
Nov 4, 2008·The Journal of Pain : Official Journal of the American Pain Society·Lisa M ZelinskiRaymond M Quock
Apr 27, 2010·CNS Neuroscience & Therapeutics·Michael Bennett, Robert Heard
Apr 27, 2010·The Journal of Pain : Official Journal of the American Pain Society·Eunhee ChungRaymond M Quock

❮ Previous
Next ❯

Citations

Aug 28, 2015·Journal of Neuroscience Methods·Thomas K RingstedMads U Werner
Dec 16, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Karen Binkley, Rita Katznelson
Jan 13, 2021·Medicina·Christian SmolleFreyja-Maria Smolle-Juettner
Mar 25, 2021·European Journal of Pain : EJP·Charles QuesadaLuis Garcia-Larrea
Jul 31, 2021·PloS One·Anders Deichmann SpringborgMads Utke Werner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Deutsche medizinische Wochenschrift
G RICHTERR FREY
Agressologie: revue internationale de physio-biologie et de pharmacologie appliquées aux effets de l'agression
G BERTHARION, L BARTHELEMY
© 2022 Meta ULC. All rights reserved