Hyperbaric oxygen therapy for chronic antibiotic-refractory ischemic pouchitis

Gastroenterology Report
Custon T NyabangaBo Shen

Abstract

Hyperbaric oxygen therapy (HBOT) has been shown to be efficacious in treating various conditions, including perianal Crohn's disease. Here we present a case of a 59-year-old male with a history of ulcerative colitis, who underwent a total proctocolectomy and two-stage J-pouch construction. He later developed chronic antibiotic-refractory pouchitis with endoscopic features of ischemia. At the completion of HOBT-a total of 20 sessions of 100% oxygen at 2.5-3.0 atmospheres absolute for 60-90 minutes per session-a repeat pouchoscopy showed marked improvement of endoscopic mucosal inflammation. HBOT is known to increase tissue oxygenation, reduce tissue hypoxia, alter inflammatory pathways and promote tissue healing. This case demonstrated the therapeutic role of HBOT as well as the possible disease mechanism in chronic antibiotic-refractory pouchitis.

References

Jun 23, 2004·QJM : Monthly Journal of the Association of Physicians·A L Gill, C N A Bell
Dec 10, 2009·Inflammatory Bowel Diseases·Bo ShenJohn R Goldblum
Jan 29, 2014·Plastic and Reconstructive Surgery·Phillip B DauweRod J Rohrich
Apr 18, 2014·Alimentary Pharmacology & Therapeutics·P S DulaiC A Siegel

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Citations

Oct 9, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Xian-Rui WuBo Shen
Nov 19, 2019·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Trung T NguyenMayland Chang
Nov 2, 2019·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Rutger C LalieuRob A van Hulst
Mar 17, 2020·Diabetes/metabolism Research and Reviews·Prashanth VasFran Game
Jan 14, 2020·Diabetes/metabolism Research and Reviews·Magnus Löndahl, Andrew J M Boulton

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