Hyperbaric Oxygen Therapy for Second-Degree Burn Healing: An Experimental Study in Rabbits

Advances in Skin & Wound Care
Mendy J HatibieLeo Rendy

Abstract

The wound healing process includes inflammation, proliferation, and remodelling phases, the main features of which are inflammation, neoangiogenesis, and epithelialization. Hyperbaric oxygen therapy (HBOT) is one modality postulated to improve wound healing. The objective of this study was to determine whether HBOT could improve selected features of burn wound healing in an experimental rabbit model. Researchers conducted an experimental study with 36 rabbits given second-degree burns. Subjects were separated into two groups: a control group (n = 18) and an intervention group that was given HBOT at 2.4 atmospheres absolute for 6 days (n = 18). The main outcome measure was wound healing. Compared with the control group, the HBOT group showed more robust inflammatory cells (P = .025) and epithelialization (P = .024), but no significant difference in angiogenesis (P = .442). The authors conclude that HBOT may improve second-degree burn healing by increasing inflammatory cell migration and re-epithelialization.

References

Jun 1, 1977·Archives of Surgery·H N KornT A Miller
Feb 1, 1994·Burns : Journal of the International Society for Burn Injuries·P Cianci, R Sato
May 1, 1997·Plastic and Reconstructive Surgery·J A NiezgodaA B Storrow
May 13, 1998·British Journal of Plastic Surgery·O ShoshaniY Peled
Aug 26, 2006·Critical Care Medicine·Jon A BurasWende R Reenstra
Feb 20, 2008·The Journal of Biological Chemistry·Stephen R ThomTatyana N Milovanova
Mar 1, 2001·The Physician and Sportsmedicine·J S Delaney, D L Montgomery
Nov 26, 2010·Journal of Burn Care & Research : Official Publication of the American Burn Association·Jeffrey W ShuppJames C Jeng
Jan 14, 2011·Plastic and Reconstructive Surgery·Stephen R Thom
Dec 29, 2012·Journal of Burn Care & Research : Official Publication of the American Burn Association·Caferi Tayyar SelçukSavaş Ilgezdi
Jul 10, 2013·Journal of Burn Care & Research : Official Publication of the American Burn Association·Nicole S GibranBrad Wiggins
Feb 3, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J P GrassmannM Hakimi

❮ Previous
Next ❯

Citations

Jul 2, 2019·The Korean Journal of Pain·Faraz Mahdian DehkordiMoosa Javdani
Nov 9, 2019·Wiener klinische Wochenschrift·Laurenz WeitgasserChristine Radtke
Jan 13, 2021·Medicina·Christian SmolleFreyja-Maria Smolle-Juettner

❮ Previous
Next ❯

Software Mentioned

CellD
NDP
Image Measure

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Medical Journal, Armed Forces India
Yogesh ChanderRamji Rai
Clinics in Dermatology
R N Roth, L D Weiss
Geka chiryo. Surgical therapy
K IkedaJ Wada
Eksperimental'naia khirurgiia i anesteziologiia
B Ia Rudakov
© 2022 Meta ULC. All rights reserved