Hyperbaric oxygen therapy palliates lipopolysaccharide-induced acute lung injury in rats by upregulating AQP1 and AQP5 expression

Experimental Lung Research
Guang HanHongtao Liu

Abstract

Hyperbaric oxygen (HBO) therapy has been suggested to palliate acute lung injury (ALI), but the mechanisms involved are not well understood. This study is to elucidate the involvement of AQP1 and AQP5 in the HBO related ALI therapy. lipopolysaccharide (LPS) was administrated into SD rats to obtain ALI models. Pressure of oxygen (PaO2) and carbon dioxide (PaCO2) in arterial blood and oxygenation index in rats after LPS and HBO treatments were determined. Pathological changes of the lungs were examined by hematoxylin and eosin staining. Alteration of TNF-α level during LPS and HBO treatments was evaluated with ELISA analysis. Western blot was employed to assess the expression of AQP1 and AQP5. Blood gas indexes were largely decreased by LPS administration, which responded to HBO. Pathological examination showed that the inflammation symptoms in lungs induced by LPS were also palliated after HBO preconditioning. LPS induced the expression of TNF-α at a high level which could be downregulated by HBO and TNF-α antagonist treatments. Results of AQP1 and AQP5 determination found that HBO and TNF-α antagonist would upregulate the expression of AQP1 and AQP5 which was inhibited in rats with ALI. HBO therapy palliated LPS-induced ALI in ...Continue Reading

References

Aug 12, 1967·Lancet·D G AshbaughB E Levine
Apr 17, 2002·Shock·Douglas Y TamuraChristopher C Silliman
May 25, 2002·Intensive Care Medicine·M-Y LuK-L Huang
Jun 5, 2004·Shock·Wann-Cherng PerngKun-Lun Huang
Feb 4, 2010·Acta Histochemica Et Cytochemica·Toshiyuki MatsuzakiKuniaki Takata
Oct 13, 2010·Annual Review of Pathology·Michael A Matthay, Rachel L Zemans
Oct 12, 2012·Targeted Oncology·Ingrid Moen, Linda E B Stuhr
May 9, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Yanfen ZhangXiaomin Xin
Jun 9, 2014·Medical Hypotheses·Xiaojing YeGang Zhou
Oct 23, 2014·Interventional Neurology·Zheng DingHui-Ping Peng
Dec 3, 2014·Clinics in Chest Medicine·Andrew J Sweatt, Joseph E Levitt

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Citations

Apr 14, 2016·Experimental Lung Research·Yue-Jun ChenHsiu-Chu Chou
Nov 7, 2018·Pflügers Archiv : European journal of physiology·Oliver H Wittekindt, Paul Dietl

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