Abstract
Heart rate corrected QT (QTc) interval prolongation is a risk factor associated with increased mortality. Hyperbaric oxygen therapy (HBO) has previously been shown to have acute beneficial effects on QTc dispersion. The aim of this study was to evaluate long-term effects of HBO on QTc time in diabetic patients with hard-to-heal foot ulcers. In a prospective, double-blinded placebo-controlled study, patients were randomized to 40 treatment sessions with either HBO or air (placebo), at 2.5 ATA. Patients fulfilling >35 completed treatment sessions were included in the evaluation. Of the initial 75 patients (38 HBO/37 placebo), two were excluded due to pacemaker use. Baseline characteristics were similar between groups. At the 2-year follow-up, QTc time was significantly shorter in the HBO compared to the placebo group (438 vs. 453ms, p<0.05). Further, fewer HBO treated patients had a QTc time >450ms (22 vs. 53 %, p<0.02). This difference seemed to be caused by a significant prolongation of the QTc interval in the placebo group (427 (419-459) at baseline vs. 456ms (424-469) after 2years), whereas no significant change was seen in HBO treated patients. HBO treatment might protect against QTc prolongation in this high-risk diabetic p...Continue Reading
References
Dec 19, 1991·The New England Journal of Medicine·J L WillemsG van Herpen
Jan 1, 1991·The American Journal of Cardiology·R J GoldbergD Levy
May 1, 1990·Diabetologia·R A MalikA J Boulton
Feb 1, 1989·Diabetologia·R A MalikJ D Ward
Jan 1, 1985·Diabetes Care·S MasaokaE H Hon
Jan 1, 1994·Journal of Electrocardiology·P W MacfarlaneT F Yang
Aug 1, 1994·Circulation·J M DekkerD Kromhout
Nov 1, 1993·British Heart Journal·A AlgraJ Lubsen
Dec 1, 1996·Diabetes Care·E FagliaA Morabito
Feb 18, 1998·European Journal of Clinical Investigation·N TentolourisK Papageorgiou
Sep 4, 1999·Journal of Internal Medicine·L Landstedt-HallinP E Lins
Oct 16, 1999·Acta Physiologica Scandinavica·V E LundJ Jalonen
Nov 14, 2000·The American Journal of Cardiology·A FestaS M Haffner
Nov 24, 2001·Diabetologia·N E CameronS Tesfaye
Jun 1, 2002·Journal of Diabetes and Its Complications·Majid KalaniKerstin Brismar
Oct 29, 2002·Diabetes Care·Anne L CarringtonAndrew J M Boulton
May 2, 2003·Age and Ageing·Arduino A MangoniStephen H D Jackson
Apr 20, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·T B SunT B J Kuo
Aug 16, 2006·Annals of Internal Medicine·Andrew S LeveyUNKNOWN Chronic Kidney Disease Epidemiology Collaboration
Nov 28, 2006·Journal of Wound Care·M LöndahlJ Apelqvist
May 30, 2008·The Tohoku Journal of Experimental Medicine·Ejder KardesogluSezai Ozkan
Apr 30, 2010·Diabetes Care·Magnus LöndahlChrister Hammarlund
Feb 1, 2012·Diabetes/metabolism Research and Reviews·F L GameW J Jeffcoate
Aug 10, 2012·Diabetes Care·Enrique RegidorSara Artola
Aug 15, 2012·Diabetologia·J R W BrownriggR J Hinchliffe
Feb 14, 2013·Diabetologia·K Fagher, M Löndahl
Feb 28, 2014·Diabetes Care·Amanda J CoxDonald W Bowden