Hyperbaric oxygen therapy reduces the size of Leishmania amazonensis-induced soft tissue lesions in mice

Acta Tropica
Wagner Welber Arrais-SilvaSelma Giorgio

Abstract

In this study we determined whether exposing mice to hyperbaric oxygen (HBO) would alter various disease parameters of a susceptible mouse strain infected with Leishmania amazonensis. BALB/c mice exposed to HBO (100% O2 at a pressure of 2.5 ATA, 1h before parasite inoculation and subsequently for 20 days) showed significant delay in lesion development and reduction in lesion parasite burdens compared with HBO-unexposed mice. Circulating levels of interferon gamma (IFN-gamma) and tumor necrosis factor (TNF-alpha) were significantly elevated in HBO-exposed as compared to HBO-unexposed mice. Concanavalin A-stimulated lymph nodes cultures from HBO-exposed mice released significantly more IFN-gamma and less interleukin 10 (IL-10) than cultures from HBO-unexposed mice, consistent with a skewed Th1 response. These results demonstrate, for the first time, that HBO can play a pathogen control role during leishmaniasis. Further studies are needed to elucidate whether hyperoxia alone or increased atmospheric pressure alone can exert a similar effect.

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Citations

Dec 3, 2013·Disease Models & Mechanisms·Shengyong NgSangeeta N Bhatia
Sep 4, 2012·Tissue & Cell·Larissa Tavares CyrinoSelma Giorgio
Aug 2, 2011·Brain Research·Sezen Milli AvtanBulent Ahishali
Apr 22, 2015·Archives of Dermatological Research·Alexandra Paiva Araujo, Selma Giorgio
Sep 3, 2009·The Korean Journal of Parasitology·Camila Bárbara Cantalupo LimaSelma Giorgio
Feb 23, 2012·The Korean Journal of Parasitology·Solange dos Santos CostaSelma Giorgio
Dec 21, 2011·Revista Do Instituto De Medicina Tropical De São Paulo·Diana Copi AyresSelma Giorgio
Feb 3, 2016·Infection and Immunity·Ana Carolina A V KayanoFabio T M Costa

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