Hyperbranched polymer mediated size-controlled synthesis of gadolinium phosphate nanoparticles: colloidal properties and particle size-dependence on MRI relaxivity

Nanoscale
Camille FrangvilleJean-Daniel Marty

Abstract

Hyperbranched polymers based on the poly(amidoamine), HyPAM, were used to synthesize gadolinium phosphate nanowires under mild conditions. Control of the average particle size was obtained by adjusting polymer concentration. Proton relaxivity measurements reveal an optimum particle size, reaching relaxivity values as high as 55 ± 9 mM(-1) s(-1) for r1 and 67 ± 11 mM(-1) s(-1) for r2. The colloidal stability of these hybrid systems were optimized through the use of functionalized core-shell polymers containing PEG segments and C18-PEG segments, structures which also offer the possibility of imparting additional function into the polymer-particle hybrids.

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Citations

Jul 29, 2016·Chemical Communications : Chem Comm·Quanbing MouXinyuan Zhu
Sep 22, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Neda NaseriYounes Pilehvar-Soltanahmadi
Jun 12, 2020·Nanoscale·Youfu Wang, Xinyuan Zhu
Jul 30, 2018·Journal of Materials Science. Materials in Medicine·Qing LiZushun Xu
Apr 6, 2018·Physical Chemistry Chemical Physics : PCCP·Jinchang YinYuanzhi Shao
Jul 30, 2019·International Journal of Pharmaceutics·Marjorie YonJean-Daniel Marty

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