Hypercalcaemia following the use of antibiotic-eluting absorbable calcium sulphate beads in revision arthroplasty for infection

The Bone & Joint Journal
R Kallala, Fares S Haddad

Abstract

Periprosthetic joint infection (PJI) is a devastating complication for patients and results in greatly increased costs of care for both healthcare providers and patients. More than 15 500 revision hip and knee procedures were recorded in England, Wales and Northern Ireland in 2013, with infection accounting for 13% of revision hip and 23% of revision knee procedures. We report our experience of using antibiotic eluting absorbable calcium sulphate beads in 15 patients (eight men and seven women with a mean age of 64.8 years; 41 to 83) as part of a treatment protocol for PJI in revision arthroplasty. The mean follow-up was 16 months (12 to 22). We report the outcomes and complications, highlighting the risk of hypercalcaemia which occurred in three patients. We recommend that serum levels of calcium be routinely sought following the implantation of absorbable calcium sulphate beads in orthopaedic surgery.

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Citations

Sep 4, 2015·The Bone & Joint Journal·J Parvizi, F S Haddad
Jul 18, 2017·Journal of Tissue Engineering and Regenerative Medicine·Hyungjin JungOzan Akkus
Feb 21, 2018·The International Journal of Lower Extremity Wounds·Konstantinos MarkakisFrank L Bowling
Jun 6, 2018·Current Reviews in Musculoskeletal Medicine·Douglas A ZarutaBenjamin F Ricciardi
Nov 19, 2019·Vascular and Endovascular Surgery·Brandon McGuinnessMichael Stacey
Mar 3, 2020·Journal of Bone and Joint Infection·Abdulbaset Abosala, Mohammed Ali
Jun 25, 2018·Current Reviews in Musculoskeletal Medicine·Linda I SuleimanDenis Nam
Jan 23, 2020·AACE Clinical Case Reports·Amy Vora, Sadia Ali
May 2, 2018·Current Rheumatology Reports·Ashley E LevackAlberto V Carli
Jan 23, 2020·AACE Clinical Case Reports·Angela Magdaleno, Robert A McCauley
Sep 11, 2020·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Stefano GhirardelliPier F Indelli
Nov 27, 2020·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Nequesha S MohamedRonald E Delanois
Dec 17, 2020·Tropical Medicine and Infectious Disease·Ferdinando IannottiPier Francesco Indelli
Aug 5, 2021·Journal of Bone and Joint Infection·Henry T ShuBabar Shafiq
Jul 10, 2021·The Journal of Clinical Endocrinology and Metabolism·Yasaman MotlaghzadehDeborah E Sellmeyer

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