PMID: 518139Oct 1, 1979Paper

Hypercalcaemia in rheumatoid arthritis: investigation of its causes and implications

Annals of the Rheumatic Diseases
A C KennedyC J Hillyard

Abstract

When correction was made for hypoalbuminaemia, 23 of 50 ambulant patients with definite or classical rheumatoid arthritis were found to have hypercalcaemia. When these 23 patients were studied 6 months later, 7 had hypercalcaemia as defined by the correction factor for a low serum albumin level, and 6 of these patients had raised serum ionised calcium concentrations. Biochemical studies in the 23 patients indicated evidence of hyperparathyroidism, namely, hypophosphataemia, increased serum alkaline phosphatase, hyperchloraemia, and reduced tubular reabsorption of calcium. However, serum immunoreactive parathyroid hormone concentrations were normal. Only one patient had an abnormally low serum 25-hydroxy-vitamin D result: this patient had a high level of urinary D-glucaric acid and was receiving phenobarbitone for treatment of epilepsy. The biochemical features suggestive of parathyroid overactivity were particularly found in patients with raised serum calcium levels. The cause of hypercalcaemia in rheumatoid arthritis remains to be explained.

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Citations

Sep 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C B LangmanF Glorieux
Jul 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E B MawerP J Holt
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Dec 1, 1981·Annals of the Rheumatic Diseases·D L ScottA M Bold
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Sep 1, 1985·Annals of the Rheumatic Diseases·P N SambrookJ M Zanelli
Jan 1, 1990·Annals of the Rheumatic Diseases·S H RalstonR D Sturrock
Dec 1, 1992·Clinical Rheumatology·A A KallaO L Meyers
Mar 4, 2006·Chemico-biological Interactions·Vanu Ramkumar RamprasathPanchanatham Sachdanandam
Apr 1, 1986·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S GatesN H Bell
Jan 1, 1993·Scandinavian Journal of Rheumatology·H KrögerE M Alhava
Dec 1, 1993·Arthritis and Rheumatism·A A KallaL Bewerunge
Nov 1, 1992·Journal of Endocrinological Investigation·J L ShakerJ W Findling
Jan 1, 1986·Acta Medica Scandinavica·P D ChristensenH Dieperink

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