Hypercalcemia and acromegaly--clarifying the connections. A case report and review of the literature.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Pooja ManroaAngelo Licata

Abstract

Hypercalcemia in patients with acromegaly is rare and usually due to co-existent primary hyperparathyroidism. The etiology of hypercalcemia directly related to acromegaly is debated. We present a case report of 1,25(OH)2D3-mediated hypercalcemia in a patient with acromegaly and discuss potential pathophysiological mechanisms contributing to the development of hypercalcemia late in the course of the disease. A 67-year-old female presented with classical features of acromegaly. A review of her previous photographs suggested a disease duration of approximately 10 years, and her serum calcium (Ca) was normal during this period. A biochemical work up confirmed a combined growth hormone (GH-) and prolactin (PRL-) cosecreting tumor with a GH level of 92.03 ng/mL (normal 0-3.61), an insulin-like growth factor-1 (IGF-1) level of 1,498 ng/mL (59-225), and a PRL level of 223.3 ng/mL (2-17.4). Magnetic resonance imaging (MRI) of the pituitary showed a 1.9-cm macroadenoma. Her preoperative work up revealed new onset hypercalcemia with a corrected serum Ca level of 10.7 mg/dL (8.5-10.5), an ionized Ca level of 1.37 mmol/L (1.08-1.30), a parathyroid hormone (PTH) level of 13.0 pg/mL (10-60), and a high 1,25(OH)2D3 level of 72.6 pg/mL (15-60)....Continue Reading

References

Oct 1, 1979·The Journal of Clinical Endocrinology and Metabolism·N D AdamsJ Lemann
May 18, 1978·Nature·E SpanosM R Haussler
May 1, 1976·Endocrinology·S R LancerG K Hargis
Jul 1, 1985·The Journal of Clinical Endocrinology and Metabolism·S TakamotoY Kumahara
Jul 1, 1973·Clinical Endocrinology·G SigurdssonG F Joplin
Dec 28, 1968·British Medical Journal·A NadarajahT R Fraser
Apr 1, 1981·Acta Endocrinologica·B LundO H Sørensen
Jun 1, 1962·The Journal of Clinical Investigation·J CORVILAINA BERGANS
Dec 15, 2005·The Journal of Clinical Endocrinology and Metabolism·H D WhiteJ P Vora
Oct 19, 2006·Neuroendocrinology·Eva Horvath, Kalman Kovacs
Dec 15, 2006·The New England Journal of Medicine·Shlomo Melmed
Feb 27, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Claudia PalmKarin Weber
Jan 26, 2012·American Journal of Physiology. Endocrinology and Metabolism·Pissared KhuituanNarattaphol Charoenphandhu
Apr 13, 2012·The Journal of Clinical Endocrinology and Metabolism·Peter KamenickýPhilippe Chanson
Jun 19, 2013·The Journal of Clinical Endocrinology and Metabolism·G MazziottiA Giustina

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Citations

Apr 14, 2017·The Journal of Clinical Endocrinology and Metabolism·Tina ConstantinAdriana G Ioachimescu
Oct 30, 2014·Current Opinion in Endocrinology, Diabetes, and Obesity·Jeremy R Anthony, Adriana G Ioachimescu
Jan 16, 2020·Archives of Endocrinology and Metabolism·Leandro KasukiMônica Roberto Gadelha
Jun 19, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Dieter HaffnerMaren Leifheit-Nestler

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