PMID: 3754025Jan 15, 1986Paper

Hypercalcemia and elevated serum 1,25-dihydroxyvitamin D3 in a patient with Hodgkin's lymphoma

Klinische Wochenschrift
K SchaeferD von Herrath

Abstract

A 74-year-old woman was hospitalized because of decreased appetite, fatigue, and weight loss. The laboratory examination revealed hypercalcemia, a slightly increased serum creatinine level, and a markedly elevated serum level of 1,25-dihydroxyvitamin D3. The most important finding the physical examination revealed was enlarged inguinal lymph nodes. A biopsy disclosed lymphocyte-depleted Hodgkin's disease. After steroids, but not after calcitonin, both the elevated calcitriol concentration and serum calcium normalized. In spite of intensive chemotherapy, a further episode with hypercalcemia occurred and increased 1,25-dihydroxyvitamin D3 serum levels were observed. According to the available evidence it seems probable that the humoral hypercalcemia in this patient resulted from production of 1,25-dihydroxyvitamin D3 in the tumor.

References

May 25, 1985·Lancet·M DaviesG A Lumb
Aug 1, 1986·The Journal of Clinical Investigation·D A FetchickJ F Dunn
Jan 1, 1985·The Journal of Clinical Endocrinology and Metabolism·N RosenthalA F Stewart

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Citations

Sep 1, 1990·Postgraduate Medical Journal·R KarmaliJ L O'Riordan
Jun 24, 2014·Radiology·Erik S Mittra, Guido Davidzon
Feb 23, 1987·The American Journal of Medicine·F R Singer, M Fernandez
Mar 29, 2019·Journal of Clinical and Experimental Hematopathology : JCEH·Masaki MitobeJun Takizawa
Oct 24, 2017·Veterinary Sciences·Nicole A KohartThomas J Rosol
Jan 1, 1991·Critical Reviews in Oncology/hematology·L MosekildeP Charles

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