Hypercalcemia and systemic lupus erythematosus

Arthritis and Rheumatism
L J DeftosR A Terkeltaub

Abstract

Hypercalcemia is commonly caused by the increased production of parathyroid hormone-related protein (PTHrP) by a malignancy. In fact, the demonstration of increased PTHrP production in a patient with hypercalcemia is virtually pathognomonic of malignancy. We studied a patient with systemic lupus erythematosus (SLE), generalized lymphadenopathy, and hypercalcemia. Immunohistology of 2 biopsied lymph nodes revealed the abundant expression of PTHrP and the absence of malignant transformation. Although apparently rare, PTHrP production by non-malignant lymphoid tissue may occur in SLE and should be considered in the differential diagnosis of hypercalcemia.

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Citations

Jun 25, 2008·Indian Journal of Pediatrics·Utkarsh KohliArvind Bagga
Apr 14, 2005·Clinical Nuclear Medicine·Jabour KhouryNorman Loberant
Apr 19, 2006·European Journal of Internal Medicine·Raymond FarahNicola Makhoul
Jun 12, 2002·Endocrinology and Metabolism Clinics of North America·Leonard J Deftos
Sep 16, 2011·Scandinavian Journal of Rheumatology·T P KarageorgasD Ioakeimidis
Mar 11, 2015·Endocrinology, Diabetes & Metabolism Case Reports·Jingjing JiangWei Liu
May 4, 2016·Rheumatology International·Lidan ZhaoXuan Zhang
Oct 28, 2004·Journal of Pediatric Endocrinology & Metabolism : JPEM·Meilan M RutterPhilippe F Backeljauw
Feb 2, 2011·Lupus·F Del PortoG Aliberti
Sep 1, 2005·The Journal of Clinical Endocrinology and Metabolism·Thomas P Jacobs, John P Bilezikian
Apr 10, 2013·The American Journal of Case Reports·Abdul Halim Abdul GaforFadilah Abdul Wahid
Mar 12, 2005·Arquivos brasileiros de endocrinologia e metabologia·Liliana D GalrãoMittermayer B Santiago
Jul 10, 2021·The Journal of Clinical Endocrinology and Metabolism·Yasaman MotlaghzadehDeborah E Sellmeyer

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