Hypercalcemia in a woman with hypoparathyroidism associated with increased parathyroid hormone-related protein during lactation.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
M E Shomali, D S Ross

Abstract

To report a case of postpartum hypercalcemia in a woman with hypoparathyroidism associated with increased serum concentrations of parathyroid hormone-related protein (PTHrP) during lactation. The clinical and laboratory data for our patient and the related literature are reviewed. A 35-year-old woman with long-standing surgical hypoparathyroidism treated with dihydrotachysterol and calcium carbonate gave birth to a healthy boy at 40 weeks of gestation and began lactating normally. Two and a half weeks later, hypercalcemia developed in association with nausea, vomiting, and myalgias. Subsequently, an increased serum PTHrP concentration was noted. After saline diuresis and corticosteroid therapy to correct the hypercalcemia, a normal serum calcium level was maintained without vitamin D preparations or calcium supplements until the 12th postpartum week, when hypocalcemia reappeared. The serum PTHrP level was no longer increased, and treatment with calcitriol and calcium carbonate was resumed. Subsequent serum calcium concentrations have been normal. This case suggests that PTHrP stimulation of the parathyroid hormone-PTHrP receptor during lactation may compensate for the absence of parathyroid hormone in lactating women with hypop...Continue Reading

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Citations

Jan 19, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E SegalS Ish-Shalom
May 26, 2012·Indian Journal of Endocrinology and Metabolism·Shriraam MahadevanR Bharath
Nov 24, 2011·Endocrinology and Metabolism Clinics of North America·Christopher S Kovacs
Nov 29, 2005·Endocrinology and Metabolism Clinics of North America·Christopher S Kovacs, Ghada El-Hajj Fuleihan
Jun 18, 2004·Obstetrics and Gynecology Clinics of North America·Shahla Nader
May 6, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C S Kovacs, S H Ralston
Jul 15, 2015·European Journal of Endocrinology·Jens BollerslevUNKNOWN European Society of Endocrinology
Apr 4, 2021·Journal of Clinical Medicine·Dalal S AliAliya A Khan
Jul 10, 2021·The Journal of Clinical Endocrinology and Metabolism·Sigridur BjörnsdottirOlle Kämpe

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