PMID: 3757916Apr 1, 1986Paper

Hypercalcemia in glucocorticoid withdrawal

Endocrinologia Japonica
K SuzukiS Tarui

Abstract

We found severe hypercalcemia in the course of hydrocortisone withdrawal in a patient who had undergone unilateral adrenalectomy to resect a cortisol-hypersecreting adenoma. Serum calcium gradually but progressively increased after unilateral adrenalectomy. Severe hypercalcemia developed on the 77th postoperative day (the 15th day after discontinuing hydrocortisone replacement). The serum concentration of calcium, PTH, 25(OH)D, and 1,25(OH)2D were 8.0 mEq/l, less than 100 pg/ml, 10.1 ng/ml and 29.6 pg/ml, respectively. This hypercalcemia was accompanied by marked urinary hydroxyproline excretion and less calcium excretion in the urine than the prevailing level of serum calcium. Serum concentrations of 25(OH)D, 1,25(OH)2D and PTH were not elevated during the severe hypercalcemia. We concluded that the hypercalcemia in this patient was due in part to enhanced bone resorption and increased renal tubular reabsorption of calcium as a result of glucocorticoid withdrawal, but not to the elevation of serum PTH or serum 25(OH)D and serum 1,25(OH)2D.

Citations

Aug 20, 2009·The Journal of Small Animal Practice·A G GowR J Mellanby
Aug 16, 2003·Endocrine Reviews·Ze'ev HochbergGeorge P Chrousos
Dec 22, 2017·Journal of the Endocrine Society·Melissa J SchoelwerErik A Imel
Dec 12, 2017·Internal Medicine·Erina Yuasa-ShibasakiMasanobu Yamada
Sep 1, 2005·The Journal of Clinical Endocrinology and Metabolism·Thomas P Jacobs, John P Bilezikian
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·H C Taylor, M Y Ali
Mar 30, 2012·Clinics and Practice·Svetlana KatsnelsonMarina M Charitou
Jul 10, 2021·The Journal of Clinical Endocrinology and Metabolism·Yasaman MotlaghzadehDeborah E Sellmeyer

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