Hypercalcemia with nephrocalcinosis and impaired renal function due to increased Parathyroid hormone secretion at onset of childhood acute lymphoblastic leukemia

Leukemia & Lymphoma
Petra LankischRüdiger Wessalowski

Abstract

The present case report contributes new aspects to the etiology and the appearance of hypercalcemia at the onset of childhood acute lymphoblastic leukemia [ALL]. Malignancy associated hypercalcemia is often associated with an increase of Parathyroid hormone-related protein [PTHrP]. In our case PTHrP was normal but high levels of Parathormon [PTH] were measured. This increase of PTH was not due to hyperparathyroidism nor was it due to osteolytic lesions or metabolic disease interfering with bone density. The most likely explanation for high PTH levels in our case was that PTH was secreted by leukemic blasts and thus responsible for hypercalcemia. Uncommonly, hypercalcemia was clinically associated with moderate renal impairment and marked nephrocalcinosis.

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Citations

May 14, 2005·Journal of Pediatric Hematology/oncology·Elpis MantadakisMaria Kalmanti
Aug 4, 2009·Journal of Pediatric Hematology/oncology·Amita TrehanSimon Bailey
Nov 30, 2005·European Journal of Haematology·Theodosios D FilippatosMoses S Elisaf
Apr 10, 2010·British Journal of Haematology·Jeremy T S Sargent, Owen P Smith
Jan 31, 2006·Arquivos brasileiros de endocrinologia e metabologia·Maria Lucia F de Farias
Feb 28, 2017·The American Journal of Case Reports·David Toro-TobónJan M Bruder

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