Hypercalcemic hyperparathyroidism and hypophosphatemic osteomalacia complicating neurofibromatosis

Calcified Tissue International
R S Weinstein, R L Harris

Abstract

Neurofibromatosis is sometimes complicated by impaired renal tubular reabsorption of phosphate, hypophosphatemia, and osteomalacia. Hyperparathyroidism has also been reported in patients with neurofibromatosis. When hypercalcemia and elevated levels of parathyroid hormone are found in osteomalacia, however, it may be difficult to determine if the hyperparathyroidism was primary or tertiary. We describe a patient with neurofibromatosis, hypercalcemic hyperparathyroidism, hypophosphatemic osteomalacia, vitamin D deficiency, and clear-cell hyperplasia of all four parathyroid glands. Serial biomechanical, bone biopsy, and densitometric studies confirmed that treatment with ergocalciferol, calcium, and phosphate supplements significantly improved the osteomalacia but caused increased parathyroid overactivity. After subtotal parathyroidectomy, the parathyroid hormone concentration became normal and the bone mineral content increased at the spine and hip, but inappropriate phosphaturia persisted. The findings indicate that hyperparathyroidism, osteomalacia, and vitamin D deficiency adversely affect each other.

References

Aug 16, 1975·Lancet·R J Walton, O L Bijvoet
Mar 1, 1979·American Journal of Surgery·S ChakrabartiE J Arida
Apr 1, 1978·AJR. American Journal of Roentgenology·J F Holt
Dec 29, 1988·The New England Journal of Medicine·R S Weinstein, N H Bell
Dec 1, 1985·La Revue de médecine interne·M J WattiauxP Godeau
Aug 17, 1968·British Medical Journal·D R DaviesL Watson
Jun 1, 1984·Southern Medical Journal·M G FreimanisN A Samaan
Jun 1, 1984·The Journal of Clinical Endocrinology and Metabolism·R S WeinsteinB B Gallagher
Dec 31, 1981·The New England Journal of Medicine·V M Riccardi
Aug 1, 1982·Metabolism: Clinical and Experimental·R S Weinstein, L J Sappington
May 1, 1952·The Journal of Bone and Joint Surgery. British Volume·C E DENT
Nov 1, 1954·The British Journal of Radiology·G F SWANN
May 28, 1955·British Medical Journal·P D SAVILLEM CAREY

❮ Previous
Next ❯

Citations

May 6, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S SeitzM Amling
Nov 29, 2011·Archives of Dermatological Research·Luigi PetramalaClaudio Letizia
Aug 2, 2008·BMC Medicine·Mateusz KolanczykStefan Mundlos
Oct 12, 2011·Journal of the Indian Society of Pedodontics and Preventive Dentistry·S Vivekanandan
Sep 1, 1993·The American Journal of the Medical Sciences·A B Kent, R S Weinstein
May 1, 1991·The American Journal of the Medical Sciences·K KonishiF Davatchi
Sep 11, 2018·Endocrine, Metabolic & Immune Disorders Drug Targets·Vincenzo TriggianiVito Angelo Giagulli
Jan 6, 2005·Endocrine Reviews·Stephen J Marx, William F Simonds
Nov 1, 1996·Annals of Clinical Biochemistry·J K LiC S Cockram

❮ Previous
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