PMID: 9183409Apr 1, 1997Paper

Hypercalciuria: etiologies and treatment

Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
R Dumas

Abstract

Hypercalciuria is a rare biological symptom with multiple possible etiologies in children. Normal calcium excretion rate in children is defined as lower than 4 mg/kg per day, significantly higher values being observed in infants. When using urinary calcium: creatinine ratio, normal values are below 0.22 mg/mg in children, and below 0.6 to 0.8 mg/mg in infants. In our experience half patients with hypercalciuria have idiopathic hypercalciuria. Idiopathic hypercalciuria can be hereditary with a dominant autosomal mode of inheritance. Its pathophysiology is unclear, increased calcium intestinal absorption and impaired renal tubular calcium reabsorption being the two main underlying anomalies. Patients with hypercalciuria should be informed about the risk of urolithiasis and its possible prevention by a high water intake. In those patients with nephrocalcinosis or recurrent episodes of lithiasis, hydrochlorothiazide can be effective in reducing hypercalciuria. However, adverse effects of hydrochlorothiazide on serum lipids have been recently reported and make this treatment questionable in the long term.

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Citations

Jul 1, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Neamatollah AtaeiFatemeh Ataei
Aug 7, 2018·EFSA Journal·UNKNOWN EFSA Panel on Dietetic Products, Nutrition and Allergies (EFSA NDA Panel)Monika Neuhäuser-Berthold

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