Hypercaloric Diet Establishes Erectile Dysfunction in Rat: Mechanisms Underlying the Endothelial Damage

Frontiers in Physiology
Iara L L de SouzaBagnólia A da Silva

Abstract

Obesity is characterized by an excessive increase in body mass, leading to endothelial damage that may favor the development of erectile dysfunction (ED). ED is defined as the inability to achieve or maintain a penile erection long enough to have a sexual intercourse. In this context, different ED models were developed, however the high price of special animals or the long period to establish the disease has limited studies in this field. Therefore, this study proposed to establish and characterize a novel model of ED in rats associated to a hypercaloric diet consumption. Animals were randomly divided into control group (CG), which received a standard diet, and obese group (OG), fed with a hypercaloric diet during 8 weeks. Rat's erectile function was evaluated in vivo and in vitro. Food and caloric intake of OG were reduced compared to CG, due to an increased diet energy efficiency. However, OG presented an increased body mass, inguinal, retroperitoneal and epididymal adipose tissues, as well as body adiposity index at the end of experimental protocol. In erectile function analysis, there was a decrease in the number and the latency of penile erections in OG. Additionally, the contractile reactivity of corpus cavernosum was inc...Continue Reading

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Citations

Aug 7, 2018·The World Journal of Men's Health·Ki Hak MoonYong Woon Kim
Oct 18, 2018·International Journal of Impotence Research·Jorge L Alves-PereiraCristiane da Fonte Ramos
Jun 4, 2020·International Journal of Impotence Research·Richard J FantusNelson E Bennett
Jul 21, 2020·Oxidative Medicine and Cellular Longevity·Anderson Fellyp Avelino DinizBagnólia Araújo da Silva
Dec 1, 2018·Oxidative Medicine and Cellular Longevity·Iara L L de SouzaBagnólia A da Silva
Mar 21, 2021·The Journal of Sexual Medicine·Fernanda PrivieroR Clinton Webb
Jul 21, 2021·The Journal of Sexual Medicine·Tomoya KataokaKazunori Kimura
Feb 25, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lei ChenGuang-Jiang Shi

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Methods Mentioned

BETA
dissection
MDA

Software Mentioned

GraphPad Prism®
AQCAD®
GraphPad
Leica Qwin

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