PMID: 7932278Mar 1, 1994Paper

Hypercapneic ventilatory response in patients with panic disorder before and after alprazolam treatment and in pre- and postmenstrual women

Journal of Psychiatric Research
S M FishmanJ F Rosenbaum

Abstract

We tested the ventilatory and anxiety response to hypercapneic (CO2) challenge in women with panic disorder as well as in normal women in the premenstrual phase and mid-points of their menstrual cycles. Panic disorder patients were challenged on two occasions, each time while in the premenstrual phase of the menstrual cycle, receiving an open trial of alprazolam through the intervening 8 weeks between tests. This study confirms previous reports indicating increased sensitivity to CO2 in patients with panic disorder and that this sensitivity can be attenuated by treatment. We found a significant decrease in the ventilatory response of panic disorder patients comparing pre- and post-therapy. We also observed that normal females, while in the premenstrual phase of their menstrual cycle, have a heightened anxiety response to CO2 challenge.

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Citations

Dec 5, 1997·Biological Psychiatry·J M GormanD F Klein
Apr 1, 2004·Acta Neuropsychiatrica·Giampaolo PernaLaura Bellodi
Aug 19, 2008·Respiratory Physiology & Neurobiology·Antonio E NardiWalter A Zin
Nov 10, 2004·Clinical Psychology Review·Kristin Vickers, Richard J McNally
Oct 18, 2003·The Psychiatric Clinics of North America·Teresa A Pigott
Aug 6, 2010·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Alicia E Meuret, Thomas Ritz
Dec 8, 2004·Journal of Psychopharmacology·Koen Schruers, Eric Griez
May 15, 2002·Journal of Clinical Psychopharmacology·Giampaolo PernaLaura Bellodi
Dec 15, 2010·Physiological Measurement·P ZakharovM S Talary

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