PMID: 2496082Mar 1, 1989Paper

Hypercapnia and response of cerebral blood flow to hypoxia in newborn lambs

Journal of Applied Physiology
J MassikR J Traystman

Abstract

Individual effects of hypoxic hypoxia and hypercapnia on the cerebral circulation are well described, but data on their combined effects are conflicting. We measured the effect of hypoxic hypoxia on cerebral blood flow (CBF) and cerebral O2 consumption during normocapnia (arterial PCO2 = 33 +/- 2 Torr) and during hypercapnia (60 +/- 2 Torr) in seven pentobarbital-anesthetized lambs. Analysis of variance showed that neither the magnitude of the hypoxic CBF response nor cerebral O2 consumption was significantly related to the level of arterial PCO2. To determine whether hypoxic cerebral vasodilation during hypercapnia was restricted by reflex sympathetic stimulation we studied an additional six hypercapnic anesthetized lambs before and after bilateral removal of the superior cervical ganglion. Sympathectomy had no effect on base-line CBF during hypercapnia or on the CBF response to hypoxic hypoxia. We conclude that the effects of hypoxic hypoxia on CBF and cerebral O2 consumption are not significantly altered by moderate hypercapnia in the anesthetized lamb. Furthermore, we found no evidence that hypercapnia results in a reflex increase in sympathetic tone that interferes with the ability of cerebral vessels to dilate during hypo...Continue Reading

Citations

Oct 16, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Andrew P HarrisRaymond C Koehler
Apr 21, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Varsha JainFelix W Wehrli
Aug 28, 2019·Circulation Research·Frank M FaraciJohn A Wemmie
Dec 20, 2005·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Lucia SpicuzzaLuciano Bernardi
Mar 27, 2021·Physiological Reviews·Jurgen A H R ClaassenFrank M Faraci

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