Hypercapnia in overlap syndrome: possible determinant factors

Sleep & Breathing = Schlaf & Atmung
Onofrio RestaMonica Carbonara

Abstract

We retrospectively evaluated data from 213 consecutive patients; 152 were affected by obstructive sleep apnea (OSA), 29 had OSA associated with chronic obstructive pulmonary disease (COPD), also known as overlap syndrome, and 32 had COPD. Patients with obesity-hypoventilation syndrome were not included. The aims of the study were to evaluate the anthropometric, pulmonary, and polysomnographic characteristics of patients affected by overlap syndrome compared to "simple" OSA and to COPD subjects and to analyze the determinants of hypercapnia in overlap syndrome. In the comparison between overlap and OSA patients, the overlap group had a significantly higher PaCO2 (44.59 vs. 39.22 mm Hg; p < 0.01), in the presence of a similar AHI (40.46 vs. 41.59/h). Comparing overlap to COPD patients, overlap showed a significantly higher PaCO2 value (44.59 vs. 39.63 mm Hg; p < 0.005) and had significantly less severe obstructive impairment (FEV 162.93 vs. 47.31%; FEV1/FVC ratio 66.71 vs. 59.25%; p < 0.005). Anthropometric, pulmonary function, and polysomnographic data did not differ between normo- and hypercapnic overlap patients. The best model (stepwise multiple regression analysis) for predicting PaCO2 in overlap patients showed r2 value 0.6...Continue Reading

References

Jan 1, 1995·American Journal of Respiratory and Critical Care Medicine·A ChaouatR Kessler
May 24, 2000·The Netherlands Journal of Medicine·O RestaT Giliberti
Aug 18, 2004·Sleep Medicine Reviews·E WeitzenblumJ Krieger

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Citations

Mar 8, 2012·Chest·Gordon E CarrBrian K Gehlbach
Mar 7, 2014·International Journal of Chronic Obstructive Pulmonary Disease·Nils Henrik HolmedahlJon Andrew Hardie
Feb 11, 2014·Herz·H Watz, M Arzt
Mar 17, 2004·Current Opinion in Pulmonary Medicine·Kesavan Kutty
Dec 15, 2007·Chest·Naoko KawataTakayuki Kuriyama
Apr 17, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jeremy P WrobelTrevor J Williams
Mar 11, 2021·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Chirag DaveAlice M Turner

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