PMID: 2497432Jan 1, 1989Paper

Hypercapnia in relation to pulmonary function in Duchenne muscular dystrophy

Pediatric Pulmonology
G J CannyH Levison

Abstract

Arterialized blood gases were analyzed in 143 patients with Duchenne muscular dystrophy (DMD) to assess the relationship between forced vital capacity (FVC) and hypercapnia. The majority of patients studied had PaCO2 values in the low or normal range. Only six older patients had hypercapnia (PaCO2 greater than or equal to 45 mm Hg), and all these patients had FVC values less than or equal to 40% predicted. We conclude that hypercapnic respiratory failure occurs as a late preterminal event in DMD.

References

Sep 1, 1977·The American Journal of Medicine·D J RileyN H Edelman
May 7, 1987·The New England Journal of Medicine·P E SmithE J Campbell
Jan 1, 1987·The American Journal of Medicine·W VinckenM G Cosio
Apr 1, 1985·Archives of Physical Medicine and Rehabilitation·M L SplaingardG M Harrison
Jan 1, 1972·Chest·E J HapkeJ Jacobs
Aug 1, 1980·The American Journal of Medicine·R BéginB Lemieux
May 1, 1980·British Medical Bulletin·J Newsom-Davis

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