Hypercapnia Modulates the Activity of Adenosine A1 Receptors and mitoK+ATP-Channels in Rat Brain When Exposed to Intermittent Hypoxia.

Neuromolecular Medicine
P P TregubD A Kuzovkov

Abstract

The mechanisms and signaling pathways of the neuroprotective effects of hypercapnia and its combination with hypoxia are not studied sufficiently. The study aims to test the hypothesis of the potentiating effect of hypercapnia on the systems of adaptation to hypoxia, directly associated with A1-adenosine receptors and mitochondrial ATP-dependent K+ -channels (mitoK+ATP-channels). We evaluated the relative number of A1-adenosine receptors and mitoK+ATP-channels in astrocytes obtained from male Wistar rats exposed to various respiratory conditions (15 times of hypoxia and/or hypercapnia). In addition, the relative number of these molecules in astrocytes was evaluated on an in vitro model of chemical hypoxia, as well as in the cerebral cortex after photothrombotic damage. This study indicates an increase in the relative number of A1-adenosine receptors in astrocytes and in cells next to the stroke region of the cerebral cortex in rats exposed to hypoxia and hypercapnic hypoxia, but not hypercapnia alone. Hypercapnia and hypoxia increase the relative number of mitoK+ATP-channels in astrocytes and in cells of the peri-infarct region of the cerebral cortex in rats. In an in vitro study, hypercapnia mitigates the effects of acute chem...Continue Reading

References

May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·C HeurteauxM Lazdunski
Oct 23, 1998·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·A BarthU Zwiener
Jun 16, 1999·Nitric Oxide : Biology and Chemistry·I Y MalyshevA F Vanin
Sep 25, 1999·The Journal of Biological Chemistry·S P GossB Kalyanaraman
Dec 9, 2000·American Journal of Respiratory and Critical Care Medicine·J G LaffeyB P Kavanagh
Jan 5, 2002·Journal of Pharmacological and Toxicological Methods·P H PevsnerJ A Koutcher
May 11, 2002·Basic Research in Cardiology·Jan NeckárFrantisek Kolár
Oct 23, 2002·ILAR Journal·Ralph B DellRajasekhar Ramakrishnan
Sep 25, 2003·Physiological Reviews·Derek M Yellon, James M Downey
Oct 4, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ute LindauerUlrich Dirnagl
May 12, 2004·Biochimica Et Biophysica Acta·Yuliya A DahlemDetlef Siemen
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Frank R SharpMyriam Bernaudin
Mar 7, 2006·Nature Reviews. Drug Discovery·Kenneth A Jacobson, Zhan-Guo Gao
Jun 1, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Keita MayanagiDavid W Busija
Sep 9, 2006·American Journal of Respiratory and Critical Care Medicine·Spyros ZakynthinosTheodoros Vassilakopoulos
Jul 5, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiu-Lan SunGang Hu
Jan 16, 2008·Physiological Reviews·Tihomir Paul Obrenovitch
Mar 12, 2008·High Altitude Medicine & Biology·Valeriy B ShatiloTatiana V Serebrovskaya
Aug 30, 2008·European Journal of Pharmacology·Olga BjörklundBertil B Fredholm
Jan 21, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Albert M I Barth, Istvan Mody
Feb 12, 2011·Journal of Neurotrauma·Christina HaubrichMarek Czosnyka
Jan 26, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jing SunLize Xiong
Oct 3, 2013·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Pavel TregubAndrey Bespalov
Feb 11, 2014·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Casey D KniffinKaren G Burnett
Dec 17, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Pavel TregubIlya Osipov
Jul 16, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Carlos C FaracoManus J Donahue
Sep 24, 2015·Bulletin of Experimental Biology and Medicine·N V KuvachevaA B Salmina
Oct 13, 2015·Progress in Neurobiology·Zhongwu Liu, Michael Chopp
Nov 12, 2015·Frontiers in Neuroscience·Elena Rybnikova, Mikhail Samoilov

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.