Hypercarbic periodic breathing during sleep in a child with a central nervous system tumor

The American Review of Respiratory Disease
S T KunaL C Murchison

Abstract

A 4-yr-old girl with a ganglioglioma involving the cerebellum and pons presented with CO2 retention and arterial O2 desaturation during wakefulness and sleep. Despite the presence of a regular respiratory pattern during wakefulness, NREM sleep was associated with the appearance of a sustained periodic respiratory pattern characterized by clusters of usually two breaths separated by an 8 to 10-s expiratory pause. At sleep onset, this Biot's respiratory pattern appeared immediately after a sigh. Breathing frequency during NREM sleep became regular with administration of supplemental O2 and an attendant increase in end-tidal CO2. Shortly after withdrawal of supplemental O2 during NREM sleep, the periodic pattern resumed and was again immediately preceded by a sigh. The observations during NREM sleep in this patient with a central nervous system abnormality indicate that Biot's type respiratory pattern may be reversed by administration of supplemental oxygen. The results in this patient suggest: (1) the presence of a very elevated CO2 apnea threshold, and (2) that the pons may play a role in determining the effect of hypercapnic hypoxia on respiratory pattern during sleep.

References

Aug 1, 1975·Journal of Applied Physiology·W M Saint JohnJ N Pasley
Oct 1, 1986·Journal of Applied Physiology·L R KlineA I Pack
Sep 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J B Skatrud, J A Dempsey
Jan 1, 1983·Sleep·R Perez-PadillaM H Kryger
Mar 1, 1981·Acta Physiologica Scandinavica·N S CherniackI Homma

❮ Previous
Next ❯

Citations

Sep 29, 1999·Progress in Neurobiology·E Nattie
Apr 17, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Eelco F M Wijdicks
Jun 4, 2013·Respiratory Physiology & Neurobiology·Amy LeeJeffrey G Ojemann
Oct 24, 2001·Journal of Child Neurology·C IoosF Cheliout-Héraut
Oct 10, 2009·International Journal of Toxicology·Michele L ContiMadhusoodana P Nambiar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.