[Hypercarotenaemia in an infant].

Annales de dermatologie et de vénéréologie
A MaruaniG Lorette

Abstract

Hypercarotenaemia is the consequence of high serum carotenoid levels, which are deposited in the stratum corneum and give a yellowish coloration to the skin. It can be distinguished from jaundice by the absence of colouring of the conjunctivae as well as orange discolouration of the palms and soles. We report a rare case of hypercarotenaemia in a child that began at the age of three months. Clinical signs and symptoms included yellowish discolouration of the skin, orange palms and soles, xerosis and pruritus. Hypercarotenaemia was confirmed by high levels of serum carotenoids. Serum vitamin A was normal. Dietary and drug-induced causes of hypercarotenaemia were excluded in this case, as well as other classical metabolic causes (renal insufficiency, malabsorption syndrome, diabetes, hypothyroidism). The child was placed on a low-carotenoids diet for six months, resulting in decreased serum carotenoid levels and regression of cutaneous signs and symptoms, especially pruritus. Although pruritus has never been reported in isolated hypercarotenaemia it is a classical sign of hypervitaminosis A. The mechanism of pruritus is not understood in this instance since vitamin A levels were normal. This case report is also unusual in that no...Continue Reading

References

Mar 26, 2003·International Journal of Dermatology·Nitsan MaharshakHenri Trau
Jun 14, 2003·Annals of Clinical Biochemistry·R Saldana ChaparroJ L Barron
Jun 10, 2005·American Journal of Clinical Dermatology·Renata Strumia
Aug 18, 2006·Current Opinion in Pediatrics·Cindy Jao-Tan, Elena Pope
Apr 7, 2007·Journal of Pediatric Orthopedics·Matthew D Saltzman, Erik C King
Jul 20, 2007·Journal of the American Academy of Dermatology·Justin M HaughtJoseph C English

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