Hypercarotenodermia in Zambia: which children turned orange during mango season?

European Journal of Clinical Nutrition
Sherry A TanumihardjoJustin Chileshe

Abstract

Vitamin A (VA) deficiency is a public health problem in many countries. The World Health Organization recommends high-dose VA supplements to children aged 6-59 months based on unequivocal evidence that supplements decreased mortality risk. VA supplements were meant as a temporary intervention until more sustainable approaches could be implemented. Fortification of processed foods with preformed VA is a means to improve VA status. The most recent addition of retinyl palmitate to cooking oil in countries that may also fortify margarine and milk will undoubtedly have a positive impact on VA status. However, quantitative measures have not been used to assess the underlying VA status of the groups who have adopted widespread fortification. The addition of preformed VA to otherwise adequate diets in VA may cause excessive total body stores. Monitoring population status will require accurate VA assessment to ensure that hypervitaminosis does not prevail. This perspective describes a cohort of rural Zambian children who have adequate diets in VA, mostly as provitamin A carotenoids; who were given high-dose VA supplements till the age of 5 years; who have access to VA-fortified sugar; and whose mothers had access to VA-fortified sugar t...Continue Reading

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Aug 5, 2015·The American Journal of Clinical Nutrition·Sherry A TanumihardjoJustin Chileshe

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Citations

Dec 23, 2016·Annals of the New York Academy of Sciences·Aurélie Bechoff, Claudie Dhuique-Mayer
Apr 26, 2017·Experimental Biology and Medicine·Emily Taylor NussSherry A Tanumihardjo
Sep 29, 2018·Annals of the New York Academy of Sciences·Sherry A TanumihardjoMartha E van Stuijvenberg
Feb 27, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Chisela KaliwileSherry A Tanumihardjo
Mar 13, 2018·Food and Nutrition Bulletin·Tyler J TitcombSherry A Tanumihardjo
Feb 12, 2017·Annals of the New York Academy of Sciences·Sherry A TanumihardjoKevin V Pixley
Apr 25, 2020·Experimental Biology and Medicine·Jesse SheftelSherry A Tanumihardjo
Dec 4, 2019·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Johannes von LintigSrinivasagan Ramkumar
Feb 26, 2021·Journal of Lipid Research·Srinivasagan RamkumarJohannes von Lintig
Jul 13, 2021·European Journal of Nutrition·Geereddy Bhanuprakash ReddyHarshpal S Sachdev

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